Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo, 060-0061, Japan.
Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Med Mol Morphol. 2023 Jun;56(2):85-93. doi: 10.1007/s00795-023-00348-x. Epub 2023 Feb 7.
In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast, colorectal and prostate tumors. Given the pleiotropic cellular activity of vitamin D, its deficiency impairs its physiological function in target cells and results in various pathologies including cancer. In addition, accumulated data have shown that elevated expression of CYP24A1 promotes carcinogenesis in various cancer subtypes by decreasing the bioavailability of vitamin D metabolites. Thus, we propose the potential feasibility of vitamin D metabolism-blocking therapy in various types of human malignancies that express constitutive CYP24A1.
在这篇综述中，我们讨论了维生素 D 代谢酶 CYP24A1 是否可能成为各种肿瘤（包括乳腺癌、结直肠癌和前列腺癌）的治疗靶点。鉴于维生素 D 的多效性细胞活性，其缺乏会损害其在靶细胞中的生理功能，并导致各种病理，包括癌症。此外，累积的数据表明，CYP24A1 的表达升高通过降低维生素 D 代谢物的生物利用度来促进各种癌症亚型的致癌作用。因此，我们提出了在表达组成型 CYP24A1 的各种人类恶性肿瘤中阻断维生素 D 代谢的潜在可行性。
