预测 HIV 阴性患者巨细胞病毒视网膜炎复发的因素。

Predictors for Recurrence of Cytomegalovirus Retinitis in HIV-Negative Patients.

机构信息

Department of Ophthalmology, Faculty of Medicine, Siriaj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Ocul Immunol Inflamm. 2024 Jul;32(5):493-500. doi: 10.1080/09273948.2023.2170250. Epub 2023 Feb 7.

DOI:10.1080/09273948.2023.2170250

PMID:36749945

Abstract

PURPOSE

To investigate the incidence of and predictive factors for recurrent cytomegalovirus retinitis (CMVR) in human immunodeficiency virus (HIV)-negative patients.

METHODS

A retrospective review of HIV-negative patients who were newly diagnosed with CMVR between January 2005 and February 2019.

RESULTS

Of 28 patients (44 eyes), 35.9% of eyes had a recurrence of CMVR after discontinuation of anti-CMV therapy. The incidence of CMVR recurrence was 17 per 100 eye-years. The factors significantly associated with CMVR recurrence were eyes with retinitis area of more than 25% ( = .013), absence of vitreous haze ( = .003), neutropenia at presentation ( = .001), and absence of systemic immunosuppression therapy prior to presentation ( = .002).

CONCLUSION

Eyes with a large area of retinitis, absence of vitreous haze, and neutropenia at presentation are predictive of CMVR recurrence while receiving systemic immunosuppression prior to CMVR presentation has a lower risk of CMVR recurrence.

摘要

目的

研究人类免疫缺陷病毒（HIV）阴性患者中复发性巨细胞病毒视网膜炎（CMVR）的发生率和预测因素。

方法

回顾性分析了 2005 年 1 月至 2019 年 2 月期间新诊断为 CMVR 的 HIV 阴性患者。

结果

在 28 例（44 只眼）患者中，抗 CMV 治疗停止后有 35.9%的眼出现 CMVR 复发。CMVR 复发的发生率为每 100 眼年 17 例。与 CMVR 复发显著相关的因素是视网膜有超过 25%的病变区域（ = 0.013）、无玻璃体混浊（ = 0.003）、就诊时中性粒细胞减少（ = 0.001）以及就诊前无全身免疫抑制治疗（ = 0.002）。