Admani A K
Br Med J. 1978 Dec 16;2(6153):1678-9. doi: 10.1136/bmj.2.6153.1678.
Ninety-one patients with acute stroke participated in a double-blind, placebo-controlled trial of naftidrofuryl. Treatment was allocated at random and given over 12 weeks, neurological and neurophysical scores being obtained before treatment and at weeks 2, 4, 8, and 12. Both treatment groups greatly improved over the 12 weeks, but the naftidrofuryl-treated patients made greater neurological progress. Of the patients eventually discharged, those given naftidrofuryl spent only half as long in hospital as the controls. Deaths attributable to stroke were significantly fewer in the active-treatment group.
91名急性中风患者参与了一项关于萘呋胺酯的双盲、安慰剂对照试验。治疗随机分配,持续12周,在治疗前以及第2、4、8和12周获取神经学和神经物理学评分。两个治疗组在12周内均有显著改善,但接受萘呋胺酯治疗的患者在神经学方面进展更大。最终出院的患者中,接受萘呋胺酯治疗的患者住院时间仅为对照组的一半。积极治疗组中因中风导致的死亡显著减少。