Shaw S W, Johnson R H
Acta Neurol Scand. 1975 Sep;52(3):231-7. doi: 10.1111/j.1600-0404.1975.tb05777.x.
We have designed this investigation to determine whether naftidrofuryl has an effect upon metabolism in vivo in man. Five subjects were studied during and after steady exercise on a bicycle ergometer. On the first occasion they received naftidrofuryl (300 mg orally) 20-40 min before exercise; and on the second they exercised without the drug to provide control observations. Blood samples were taken for the estimation of glucose, pyruvate, lactate, glycerol, acetoacetate and 3-hydroxybutyrate. Exercise with naftidrofuryl caused a significantly greater rise in blood pyruvate concentration during the exercise and post-exercise period compared with the controls. Changes in glucose, lactate, glycerol and ketone-bodies were not significantly different from the control values. Lactate/pyruvate ratios were significantly reduced with naftidrofuryl during the post-exercise period. Exercise causes a rise in intracellular anaerobic metabolism with associated increases in blood lactate/pyruvate ratios. This is followed by enhanced oxidative capacity during the recovery period as adduced from falling lactate/pyruvate ratios. The greater decline in lactate/pyruvate ratios with naftidrofuryl during the post-exercise period is evidence that naftidrofuryl is able to enhance cellular oxidative activity in vivo in man. Further studies in clinical situations are therefore indicated.
我们设计了这项研究，以确定萘呋胺酯对人体体内代谢是否有影响。对五名受试者在自行车测力计上进行稳定运动期间及之后进行了研究。第一次，他们在运动前20 - 40分钟口服萘呋胺酯（300毫克）；第二次，他们在不服用药物的情况下进行运动以提供对照观察。采集血样以测定葡萄糖、丙酮酸、乳酸、甘油、乙酰乙酸和3 - 羟基丁酸。与对照组相比，服用萘呋胺酯进行运动在运动期间和运动后血丙酮酸浓度显著升高。葡萄糖、乳酸、甘油和酮体的变化与对照值无显著差异。运动后阶段，萘呋胺酯使乳酸/丙酮酸比值显著降低。运动导致细胞内无氧代谢增加，伴随血乳酸/丙酮酸比值升高。随后，从下降的乳酸/丙酮酸比值可推断出恢复期氧化能力增强。运动后阶段萘呋胺酯使乳酸/丙酮酸比值下降幅度更大，这证明萘呋胺酯能够增强人体体内细胞的氧化活性。因此，需要在临床情况下进行进一步研究。
