Liu Mingsheng, Yu Wenwen, Fang Yu, Zhou Haichun, Liang Yu, Huang Congshu, Liu Hongbin, Zhao Guanghui
State Key Laboratory of Applied Organic Chemistry, Institute of Biochemical Engineering & Environmental Technology, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Road, Lanzhou 730000, PR China; State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute, Xiamen 361011, PR China.
The Second Clinical Medical College, Lanzhou University, Lanzhou 730000, PR China.
Int J Pharm. 2023 Mar 5;634:122697. doi: 10.1016/j.ijpharm.2023.122697. Epub 2023 Feb 6.
Solar skin damage is one of the most common diseases among outdoor workers. An important cause for the damage is the ultraviolet and infrared rays in sunlight, which are absorbed by the skin in large amounts, leading to severe skin inflammation and oxidative stress. Therefore, physical prevention by shielding the light from harmful wavelengths can be an effective method of skin protection from radiation. However, for existing skin lesions, prompt treatment is essential to avoid the aggravation of the injury and promote repair. Therefore, to improve the therapeutic effect on sun-damaged skin, we attempted to design a system with a dual purpose of eliminating toxic free radicals and modulating tissue inflammatory response. Here, we designed and synthesized a poly-acryloyl lysine (P-Ac-Lys) and polyvinyl alcohol-dihydroxyphenylalanine (PVA-DOPA) composite hydrogel (PAL@PVA-DOPA Hydrogel) loaded with lactate and pyruvate, that exhibites a good free radical scavenging activity and an excellent ability to modulate the inflammatory response. Experimental results showe that this hydrogel film could effectively reduce the UV-induced skin inflammation response, alleviate pathological damage and promote the recovery of the damaged skin.
日光性皮肤损伤是户外工作者中最常见的疾病之一。造成这种损伤的一个重要原因是阳光中的紫外线和红外线，它们被皮肤大量吸收，导致严重的皮肤炎症和氧化应激。因此，通过遮挡有害波长的光线进行物理防护可以成为一种有效的皮肤防辐射保护方法。然而，对于现有的皮肤损伤，及时治疗对于避免损伤加重和促进修复至关重要。因此，为了提高对日光损伤皮肤的治疗效果，我们试图设计一种具有消除有毒自由基和调节组织炎症反应双重目的的系统。在此，我们设计并合成了一种负载乳酸和丙酮酸的聚丙烯酰赖氨酸（P-Ac-Lys）和聚乙烯醇-二羟基苯丙氨酸（PVA-DOPA）复合水凝胶（PAL@PVA-DOPA水凝胶），其具有良好的自由基清除活性和出色的调节炎症反应能力。实验结果表明，这种水凝胶膜可以有效减轻紫外线诱导的皮肤炎症反应，减轻病理损伤并促进受损皮肤的恢复。
