Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
Department of Respiratory Physiology and Sleep Medicine, Tokyo Medical and Dental University, Japan.
Intern Med. 2023 May 1;62(9):1323-1328. doi: 10.2169/internalmedicine.8877-21. Epub 2023 Feb 8.
Coronavirus disease 2019 (COVID-19) pneumonia is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently accompanied by various sequelae. Interstitial lung diseases (ILDs) are observed in COVID-19 pneumonia patients after recovery, probably due to persistent inflammation in the lungs. We herein report a case of ILD with anti-signal recognition particle antibodies following severe COVID-19 pneumonia. The patient was diagnosed with ILD three months after COVID-19 pneumonia. Although the exact mechanism is unknown, the autoantibody-induced immune response might have been the pulmonary fibrosis trigger in this patient.
新型冠状病毒病（COVID-19）肺炎由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起，常伴有各种后遗症。COVID-19 肺炎患者在康复后观察到间质性肺疾病（ILD），可能是由于肺部持续炎症所致。本文报告了一例严重 COVID-19 肺炎后出现抗信号识别颗粒抗体的 ILD 病例。该患者在 COVID-19 肺炎后 3 个月被诊断为 ILD。尽管确切机制尚不清楚，但自身抗体诱导的免疫反应可能是该患者肺纤维化的触发因素。
