Washington University School of Medicine, St. Louis, MO.
Washington University School of Medicine, St. Louis, MO.
Clin Lymphoma Myeloma Leuk. 2023 Apr;23(4):266-272. doi: 10.1016/j.clml.2023.01.008. Epub 2023 Jan 17.
INTRODUCTION/BACKGROUND: People with multiple myeloma are at risk for financial toxicity due to the high cost of treatment and prolonged treatment duration. However, little data exist regarding financial toxicity among people with myeloma.
In this study, a cohort of 135 patients were recruited from an ongoing observational trial to complete the Comprehensive Score for financial Toxicity (COST). Participants were sent follow-up surveys at 3, 6, and 12 months.
The median age was 68 years; the majority were non-Hispanic whites (88%), male (63%), held a college degree (61%), and had left the workforce (70%). The median time from myeloma diagnosis was 28 months. The median COST score was 27; 48% of participants had a score below 27 and considered to have financial toxicity. The only characteristic associated with financial toxicity was a college degree. After controlling for other covariates, those with a college education were 69% less likely to have financial toxicity. Of the 108 participants who completed a follow-up survey, 34% reported changes in their financial toxicity status at a subsequent time point. Transitioning from not having financial toxicity to having financial toxicity was more common than the reverse.
Because financial toxicity is a dynamic process, which patients are experiencing it at any given time is difficult to predict. Focusing the research agenda on improved detection and intervention may be warranted.
简介/背景：由于治疗费用高昂且治疗持续时间长，多发性骨髓瘤患者存在财务毒性风险。然而，目前关于骨髓瘤患者的财务毒性数据很少。
本研究从一项正在进行的观察性试验中招募了 135 名患者，让他们完成全面财务毒性评分（COST）。参与者在 3、6 和 12 个月时会收到后续调查。
中位年龄为 68 岁；大多数是非西班牙裔白人（88%）、男性（63%）、拥有大学学历（61%）和已离职（70%）。从骨髓瘤诊断到中位时间为 28 个月。COST 评分中位数为 27；48%的参与者得分低于 27，被认为存在财务毒性。唯一与财务毒性相关的特征是大学学历。在校正其他协变量后，受过大学教育的人发生财务毒性的可能性降低了 69%。在完成后续调查的 108 名参与者中，34%报告在随后的时间点其财务毒性状况发生了变化。从不具有财务毒性转变为具有财务毒性比相反情况更为常见。
由于财务毒性是一个动态的过程，因此很难预测患者在任何特定时间是否会经历财务毒性。可能需要将研究重点放在提高检测和干预上。
