Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania, Goias, Brazil.
Department of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
Oxid Med Cell Longev. 2023 Jan 30;2023:2252213. doi: 10.1155/2023/2252213. eCollection 2023.
Sepsis is defined as a life-threatening organ dysfunction due to a dysregulated host immune response to an infection. Curcumin is a yellow polyphenol derived from the rhizome of Curcuma longa with anti-inflammatory and antioxidant properties scientifically proven, a condition that allowed its use as a tool in the treatment of sepsis. Thus, the purpose of this article was to systematically review the evidence on the impact of curcumin's anti-inflammatory effect on experimental sepsis.
For this, the PubMed, MEDLINE, EMBASE, Scopus, Web of Science, and LILACS databases were used, and the research was not limited to a specific publication period. Only original articles in English using experimental models (rats or mice) of sepsis induction performed by administration of lipopolysaccharide (LPS) or cecal ligation and perforation surgery (CLP) were included in the study. Studies using curcumin in dry extract or with a high degree of purity were included. At initial screening, 546 articles were selected, and of these, 223 were eligible for primary evaluation. Finally, 12 articles with full text met all inclusion criteria. Our results showed that curcumin may inhibit sepsis-induced complications such as brain, heart, liver, lungs, and kidney damage. Curcumin can inhibit inflammatory factors, prevent oxidative stress, and regulate immune responses in sepsis. Additionally, curcumin increased significantly the survival rates after experimental sepsis in several studies. The modulation of the immune response and mortality by curcumin reinforces its protective effect on sepsis and indicates a potential therapeutic tool for the treatment of sepsis.
败血症是一种危及生命的器官功能障碍，是由于宿主对感染的免疫反应失调引起的。姜黄素是一种从姜黄根茎中提取的黄色多酚，具有抗炎和抗氧化特性，这一特性使其被科学证明可用于治疗败血症。因此，本文旨在系统地综述姜黄素的抗炎作用对实验性败血症影响的证据。
为此，我们使用了 PubMed、MEDLINE、EMBASE、Scopus、Web of Science 和 LILACS 数据库，并且研究不限于特定的出版时期。仅纳入使用脂多糖（LPS）或盲肠结扎穿孔术（CLP）诱导实验性败血症的大鼠或小鼠模型的英文原创文章，包括使用姜黄素干提取物或高纯度姜黄素的研究。在初步筛选中，共选择了 546 篇文章，其中 223 篇符合初步评估标准。最后，有 12 篇全文符合所有纳入标准。我们的研究结果表明，姜黄素可能抑制败血症引起的并发症，如脑、心脏、肝脏、肺和肾脏损伤。姜黄素可以抑制炎症因子、预防氧化应激，并调节败血症中的免疫反应。此外，在几项研究中，姜黄素显著提高了实验性败血症后的存活率。姜黄素对免疫反应和死亡率的调节增强了其对败血症的保护作用，并表明其可能成为治疗败血症的一种潜在治疗工具。
