Michel R P, Case B W, Moinuddin M
Cancer. 1979 Jan;43(1):224-36. doi: 10.1002/1097-0142(197901)43:1<224::aid-cncr2820430134>3.0.co;2-x.
Immunoblastic lymphosarcoma (ILS) is a newly recognized malignant lymphoreticular neoplasm and is included in the recent W.H.O. classification of lymphomas. This report concerns six cases of ILS studied by light, immunofluorescence (IF), and electron microscopy (EM). Four patients were female and all except one were over 50 years of age. Four patients had some immunological abnormality. Light microscopy showed a monomorphic population of immunoblasts with pyroninophilic cytoplasm and variable plasmacytoid differentiation. Intracytoplasmic IgG was demonstrated by IF in four cases, and IgA in one. Large lymphoid cells with varying proportions of polysomes, rough endoplasmic reticulum, and Golgi apparatus were seen by EM in four cases. Mean survival was 4.8 months in five cases; death in four was due to disseminated ILS. We concluded that our cases of ILS are of B cell origin, are often associated with immunological abnormalities, and carry a poor prognosis. Immunofluorescence and EM are helpful in its diagnosis.
免疫母细胞性淋巴瘤（ILS）是一种新认识的恶性淋巴网状肿瘤，被纳入世界卫生组织（W.H.O.）最近的淋巴瘤分类中。本报告涉及6例经光镜、免疫荧光（IF）和电子显微镜（EM）研究的ILS病例。4例患者为女性，除1例患者外，其余均超过50岁。4例患者有一些免疫异常。光镜显示为单一形态的免疫母细胞群，细胞质嗜派洛宁，浆细胞样分化程度不一。免疫荧光法在4例中检测到胞质内IgG，1例中检测到IgA。电子显微镜在4例中观察到具有不同比例多核糖体、粗面内质网和高尔基体的大淋巴细胞。5例患者的平均生存期为4.8个月；4例死亡原因是ILS播散。我们得出结论，我们的ILS病例起源于B细胞，常与免疫异常相关，预后不良。免疫荧光和电子显微镜有助于其诊断。
