基线血清支链氨基酸与肥胖人群体重减轻干预后胰岛素抵抗的改善有关。
Baseline Serum BCAAs are Related to the Improvement in Insulin Resistance in Obese People After a Weight Loss Intervention.
作者信息
Zhang Chenghui, Wang Suyuan, Wu Yunhong, Guo Yanhong, Wang Xi
机构信息
Endocrinology Department, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, People's Republic of China.
出版信息
Diabetes Metab Syndr Obes. 2023 Jan 19;16:179-186. doi: 10.2147/DMSO.S388117. eCollection 2023.
BACKGROUND
Branched chain amino acids (BCAAs) have been revealed to be closely related to insulin resistance and obesity. This study aimed to investigate if BCAA levels at baseline are related to an improvement in insulin resistance after implementing a weight loss program intervention.
METHODS
Stored blood samples from participants in previous trials were used for BCAA evaluation. Linear regression was used to analyze the relationship between baseline amino acid levels and changes in the insulin resistance index (HOMA-IR) and blood glucose.
RESULTS
A total of 48 participants were enrolled. After the intervention, the body weight (78.29± 12.68 vs 72.06 ± 13.30 kg, p=0.020), fasting glucose (4.76 ± 0.43 vs 4.48 ± 0.39 mmol/L, p=0.001), fasting insulin (18.41±13.58 vs 12.87±10.88, p=0.028), and HOMA-IR (4.01±3.39 vs 2.62± 2.18, p=0.018) were improved significantly. BCAA levels were related to the improvement in HOMA-IR (β=-0.006, p=0.039), and valine was found to be the most closely related to the improvement in HOMA-IR (β=-0.013, p=0.017).
CONCLUSION
The baseline BCAA is related to the improvement in insulin resistance among participants after a weight loss intervention.
背景
已发现支链氨基酸（BCAAs）与胰岛素抵抗和肥胖密切相关。本研究旨在调查在实施减肥计划干预后，基线时的BCAA水平是否与胰岛素抵抗的改善有关。
方法
使用先前试验参与者储存的血液样本进行BCAA评估。采用线性回归分析基线氨基酸水平与胰岛素抵抗指数（HOMA-IR）和血糖变化之间的关系。
结果
共纳入48名参与者。干预后，体重（78.29±12.68 vs 72.06±13.30 kg，p=0.020）、空腹血糖（4.76±0.43 vs 4.48±0.39 mmol/L，p=0.001）、空腹胰岛素（18.41±13.58 vs 12.87±10.88，p=0.028）和HOMA-IR（4.01±3.39 vs 2.62±2.18，p=0.018）均有显著改善。BCAA水平与HOMA-IR的改善相关（β=-0.006，p=0.039），且发现缬氨酸与HOMA-IR的改善关系最为密切（β=-0.013，p=0.017）。
结论
减肥干预后，参与者的基线BCAA与胰岛素抵抗的改善有关。
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