孟加拉国先兆子痫患者血清钙、钠、钾、锌和铁的分析：一项病例对照研究。
Analysis of serum calcium, sodium, potassium, zinc, and iron in patients with pre-eclampsia in Bangladesh: A case-control study.
作者信息
Uddin S M Naim, Haque Mahmodul, Barek Md Abdul, Chowdhury Mohammad Nizam Uddin, Das Abhijit, Uddin Md Giash, Islam Mohammad Safiqul
机构信息
Department of Pharmacy University of Chittagong Chittagong Bangladesh.
Department of Pharmacy Noakhali Science and Technology University Noakhali Bangladesh.
出版信息
Health Sci Rep. 2023 Feb 2;6(2):e1097. doi: 10.1002/hsr2.1097. eCollection 2023 Feb.
BACKGROUND AND AIMS
Pre-eclampsia is a particular type of pregnancy condition. Although the primary etiology of pre-eclampsia is unclear, it hypothesizes that the alteration of trace elements and macro-minerals may play a crucial function in the pathogenesis of Pre-eclampsia. Therefore, our research sought to ascertain the serum level of trace elements (zinc, iron) and macro-minerals (sodium, calcium, potassium) and their possible association with pre-eclampsia.
METHODS
The present study was conducted with 74 pre-eclampsia pregnant women (case) and 118 pregnant women having normal blood pressure (controls). Atomic Absorption Spectroscopy determined the serum level of trace components and electrolytes.
RESULTS
The researchers discovered notable differences in maternal age, gestational period, body mass index, systolic and diastolic blood pressure, hemoglobin, and creatinine level. Results of serum analysis revealed that calcium (52.06 ± 3.71 mg/L vs. 65.93 ± 2.57 mg/L, < 0.05) and potassium (63.44 ± 5.33 mg/L vs. 102.54 ± 4.25 mg/L, < 0.001) concentrations were substantially lower in the patient group than in control. Serum zinc (0.34 ± 0.02 mg/L vs. 0.52 ± 0.02 mg/L, < 0.001) and iron (0.38 ± 0.03 mg/L vs. 0.46 ± 0.02 mg/L, < 0.05) concentration were also considerably decreased in pre-eclampsia participants compared with a pregnant normotensive group. Pearson's correlation research results in the patient group revealed a connection between trace elements or macro minerals. In addition, the systolic blood pressure was positively correlated with sodium ( = 0.392, < 0.01) and negatively correlated with potassium ( = -0.257, < 0.05) in the control group.
CONCLUSIONS
This study concludes that calcium, potassium, iron, and zinc levels were lower, whereas sodium levels were higher in Bangladeshi pre-eclampsia patients compared to controls. These findings with Pearson's correlation and the inter-element relationship between the patient and a control subject results can act as critical indication factors for patients with pre-eclampsia in Bangladesh and, as a result, may require a higher intake of calcium, potassium, iron, and zinc for effective therapeutic intervention and reduce the intake of sodium.
背景与目的
子痫前期是一种特殊类型的妊娠疾病。尽管子痫前期的主要病因尚不清楚，但据推测微量元素和常量矿物质的改变可能在子痫前期的发病机制中起关键作用。因此，我们的研究旨在确定微量元素（锌、铁）和常量矿物质（钠、钙、钾）的血清水平及其与子痫前期的可能关联。
方法
本研究纳入了74例子痫前期孕妇（病例组）和118例血压正常的孕妇（对照组）。采用原子吸收光谱法测定血清中微量元素和电解质的水平。
结果
研究人员发现两组在产妇年龄、孕周、体重指数、收缩压和舒张压、血红蛋白及肌酐水平方面存在显著差异。血清分析结果显示，病例组的钙（52.06±3.71mg/L vs. 65.93±2.57mg/L，P<0.05）和钾（63.44±5.33mg/L vs. 102.54±4.25mg/L，P<0.001）浓度显著低于对照组。子痫前期患者的血清锌（0.34±0.02mg/L vs. 0.52±0.02mg/L，P<0.001）和铁（0.38±0.03mg/L vs. 0.46±0.02mg/L，P<0.05）浓度也明显低于血压正常的孕妇组。病例组的Pearson相关性研究结果显示微量元素或常量矿物质之间存在关联。此外，对照组中收缩压与钠呈正相关（r=0.392，P<0.01），与钾呈负相关（r=-0.257，P<0.05）。
结论
本研究得出结论，与对照组相比，孟加拉国子痫前期患者的钙、钾、铁和锌水平较低，而钠水平较高。这些结果以及Pearson相关性分析和病例组与对照组之间元素间关系的结果，可作为孟加拉国子痫前期患者的关键指示因素，因此，可能需要增加钙、钾、铁和锌的摄入量以进行有效的治疗干预，并减少钠的摄入量。
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