Maleki Bahman, Olfatifar Meysam, Dodangeh Samira, Ahmadi Nayebali, Gorgipour Mohammad, Javanmard Ehsan
Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran Iran.
Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Sciences, Qom, Iran.
Gastroenterol Hepatol Bed Bench. 2022;15(4):294-310. doi: 10.22037/ghfbb.v15i4.2475.
This systematic review and meta-analysis evaluated the subtyped sp. isolated from humans in Iran.
sp. is an anaerobic intestinal protozoan that infects humans as well as domestic and wild animals, i.e. mammals, amphibians, reptiles, and arthropods.
A comprehensive search for papers published before April 2022 was undertaken utilizing English and Persian databases. The following MeSH keywords were used in the electronic search: ( sp.) AND (molecular OR subtype) AND (prevalence OR epidemiology) AND Iran. The quality of the included studies was evaluated. Thereafter, a random-effects meta-analysis was conducted to estimate the pooled prevalence and odds ratios regarding the included studies.
A total of 32 studies comprised of five case-control studies and 27 cross-sectional studies met the eligibility criteria. The overall pooled prevalence of subtyped sp. in Iran was estimated to be 10% (95% confidence interval: 6 to 15%). Eight subtypes of sp. (ST1- ST7 and ST9) were identified in our study, of which ST3 was the most common subtype (0.04); 0.02-0.07). The difference in subtypes between two case and control groups in reported studies was not significant, but the odds ratio of infection by ST3 (0.98; 95% CI, 0.30 to 3.20) was higher in cases.
The current systematic review showed that with the exception of ST8 and ST12, all human sp. subtypes reported in the world are found in different parts of Iran.
本系统评价和荟萃分析评估了从伊朗人类中分离出的亚型 种。
种是一种厌氧肠道原生动物，可感染人类以及家养和野生动物，即哺乳动物、两栖动物、爬行动物和节肢动物。
利用英文和波斯文数据库对2022年4月之前发表的论文进行全面检索。电子检索中使用了以下医学主题词：（ 种） AND （分子 OR 亚型） AND （患病率 OR 流行病学） AND 伊朗。对纳入研究的质量进行了评估。此后，进行随机效应荟萃分析以估计纳入研究的合并患病率和比值比。
共有32项研究符合纳入标准，其中包括5项病例对照研究和27项横断面研究。伊朗亚型 种的总体合并患病率估计为10%（95%置信区间：6%至15%）。在我们的研究中鉴定出8种 种亚型（ST1 - ST7和ST9），其中ST3是最常见的亚型（0.04；95%置信区间，0.02 - 0.07）。报告研究中两个病例组和对照组之间亚型的差异不显著，但病例组中ST3感染的比值比（0.98；95%置信区间，0.30至3.20）更高。
当前的系统评价表明，除了ST8和ST12之外，世界上报告的所有人类 种亚型在伊朗的不同地区均有发现。
