Yuan Ze, Lin Xiao, Li Peng, Gao Yu-Jun, Yuan Kai, Yan Wei, Zhang Yu-Xin, Liu Lin, Zhu Xi-Mei, Zhang Yi-Jing, Bao Yan-Ping, Chang Su-Hua, Lu Lin, Shi Le
Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University Sixth Hospital, Peking University Institute of Mental Health, Peking University, Beijing, China.
Front Psychiatry. 2023 Jan 25;13:1090369. doi: 10.3389/fpsyt.2022.1090369. eCollection 2022.
Negative bias of emotional face is the core feature of depression, but its underlying neurobiological mechanism is still unclear. The neuroimaging findings of negative emotional recognition and depressive symptoms are inconsistent.
The neural association between depressive symptoms and negative emotional bias were analyzed by measuring the associations between resting state functional connectivity (FC), brain structures, negative emotional bias, and depressive problems. Then, we performed a mediation analysis to assess the potential overlapping neuroimaging mechanisms.
We found a negative correlation between depressive symptoms and emotional recognition. Secondly, the structure and function of the inferior and lateral orbitofrontal gyrus are related to depressive symptoms and emotional recognition. Thirdly, the thickness of the inferior orbitofrontal cortex and the FC between the inferior orbitofrontal gyrus and fusiform gyrus, precuneate and cingulate gyrus mediated and even predicted the interaction between emotion recognition and depressive symptoms. Finally, in response to a negative stimulus, the activation of the frontal pole and precuneus lobe associated with the inferior orbitofrontal gyrus was higher in participants with depressive symptoms.
The core brain regions centered on the inferior orbitofrontal cortex such as middle temporal gyrus, precuneus lobe, frontal pole, insula and cingulate gyrus are the potential neuroimaging basis for the interaction between depressive symptoms and emotional recognition.
情绪面孔负性偏向是抑郁症的核心特征，但其潜在的神经生物学机制仍不清楚。负性情绪识别与抑郁症状的神经影像学研究结果并不一致。
通过测量静息态功能连接（FC）、脑结构、负性情绪偏向和抑郁问题之间的关联，分析抑郁症状与负性情绪偏向之间的神经关联。然后，我们进行了中介分析，以评估潜在的重叠神经影像学机制。
我们发现抑郁症状与情绪识别之间存在负相关。其次，眶额下回和外侧眶额回的结构和功能与抑郁症状和情绪识别有关。第三，眶额下回皮质的厚度以及眶额下回与梭状回、楔前叶和扣带回之间的FC介导甚至预测了情绪识别与抑郁症状之间的相互作用。最后，在对负性刺激的反应中，抑郁症状参与者中与眶额下回相关的额极和楔前叶的激活更高。
以眶额下回皮质为中心的核心脑区，如颞中回、楔前叶、额极、岛叶和扣带回，是抑郁症状与情绪识别相互作用的潜在神经影像学基础。
