Chauvel-Picard Julie, Tognetti Linda, Cinotti Elisa, Habougit Cyril, Suppa Mariano, Lenoir Clement, Rubegni Pietro, Del Marmol Veronique, Berot Vincent, Gleizal Arnaud, Vercherin Paul, Dejonckheere Guillame, Raffaelli Charles, Cardot-Leccia Nathalie, Azulay Nicholas, Sudaka-Bahadoran Anne, Perrot Jean L, Bahadoran Philippe
Department of Craniomaxillofacial Surgery.
Dermatology Unit, Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, Siena, Italy.
Clin Exp Dermatol. 2023 Apr 27;48(5):468-475. doi: 10.1093/ced/llad001.
Ultrasound imaging has recently benefited from the introduction of a new 70 MHz transducer able to provide high-resolution images, i.e. ultra-high-frequency ultrasound (UHFUS).
To study the morphological features of basal cell carcinomas (BCCs) and measure BCC thickness by means of UHFUS examination.
In this retrospective multicentric study, 171 consecutive patients underwent UHFUS examination between November 2018 and May 2019 for suspected BCC. Diagnosis was confirmed by histopathology. A series of morphological parameters including echogenicity, structure, borders, shape composition (presence of intralesional structures) were investigated along with objective measurements such as thickness (maximum distance between the surface of the epidermis and the deepest part of the tumour) and width.
In total, 117 BCCs from 93 patients were examined, including superficial (n = 13; 11.1%), nodular (n = 64; 54.7%), infiltrative (n = 18; 15.4%), mixed subtypes (n = 20; 17.1%) and other subtypes (n = 2; 1.7%). The most frequently observed UHFUS parameters included: hypoechoic signal (n = 80; 68.4%, P < 0.001), homogeneous structure (n = 76, 65.0%, P = 0.01), well-defined borders (n = 77, 65.8%, P < 0.001) and elongated shape (n = 71, 60.7%, P < 0.001). An excellent correlation was found between the BCC thickness measured by UHFUS and the value estimated by histology (interclass correlation ≥ 0.80).
UHFUS is a new rapid and easy noninvasive skin imaging technique able to provide data on the dimensions and morphology of BCCs in real time and at the bedside. These characteristics mean UHFUS has a number of possible applications, ranging from presurgical mapping to the detection of disease recurrence and treatment monitoring.
超声成像技术最近受益于一种新型70 MHz换能器的引入，该换能器能够提供高分辨率图像，即超高频率超声（UHFUS）。
通过UHFUS检查研究基底细胞癌（BCC）的形态特征并测量BCC的厚度。
在这项回顾性多中心研究中，2018年11月至2019年5月期间，171例疑似BCC患者连续接受了UHFUS检查。诊断通过组织病理学得以证实。研究了一系列形态学参数，包括回声性、结构、边界、形状组成（瘤内结构的存在情况），以及诸如厚度（表皮表面与肿瘤最深部位之间的最大距离）和宽度等客观测量指标。
总共检查了93例患者的117个BCC，包括浅表型（n = 13；11.1%）、结节型（n = 64；54.7%）、浸润型（n = 18；15.4%）、混合型（n = 20；17.1%）和其他亚型（n = 2；1.7%）。最常观察到的UHFUS参数包括：低回声信号（n = 80；68.4%，P < 0.001）、均匀结构（n = 76，65.0%，P = 0.01）、边界清晰（n = 77，65.8%，P < 0.001）和细长形状（n = 71，60.7%，P < 0.001）。发现UHFUS测量的BCC厚度与组织学估计值之间具有极好的相关性（组内相关性≥0.80）。
UHFUS是一种新型快速且简便的非侵入性皮肤成像技术，能够在床边实时提供有关BCC大小和形态的数据。这些特性意味着UHFUS有许多可能的应用，从术前定位到疾病复发检测和治疗监测。
