Li Qi, Wang Zhen, Dong Vy M, Yang Xiao-Hui
Advanced Research Institute of Multidisciplinary Science, School of Chemistry and Chemical Engineering, Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, Beijing Institute of Technology, Beijing 100081, P. R. China.
Department of Chemistry, University of California-Irvine, Irvine, California 92697, United States.
J Am Chem Soc. 2023 Feb 10;145(7):3909-14. doi: 10.1021/jacs.2c12779.
As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.
作为氢官能化领域的一项进展，我们在此报告醇类能够以高区域选择性和对映选择性加成到1,3-二烯上。使用镍-双膦配体（Ni-DuPhos），我们能够得到对映体富集的烯丙基醚。通过选择无溶剂条件，我们控制了碳-氧键形成的可逆性。这项工作展示了甲醇作为不对称合成试剂的一个罕见实例。
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