无整合的唐氏综合征和等基因整倍体人类诱导多能干细胞的产生。
Generation of integration-free Down syndrome and isogenic euploid human induced pluripotent stem cells.
作者信息
Nehra Sunita, Sharma Vishi, Umrani Malati, Singhal Nishant
机构信息
Stem cell and Neurobiology Lab, National Centre for Cell Science (NCCS), Pune 411007, India.
Stem cell and Neurobiology Lab, National Centre for Cell Science (NCCS), Pune 411007, India.
出版信息
Stem Cell Res. 2023 Mar;67:103041. doi: 10.1016/j.scr.2023.103041. Epub 2023 Feb 6.
A pair of Down syndrome (DS) human iPSCs (hiPSCs) and isogenic euploid hiPSCs generated by using an integration-free Sendai viral vector system showed trisomy 21 (47; XY) and typical (46; XY) karyotype respectively. Pluripotency of both hiPSC lines was confirmed by pluripotency marker expression and three germ layer differentiation potentials.
通过使用无整合仙台病毒载体系统产生的一对唐氏综合征（DS）人诱导多能干细胞（hiPSC）和等基因整倍体hiPSC分别显示21三体（47；XY）和典型的（46；XY）核型。两种hiPSC系的多能性通过多能性标志物表达和三个胚层分化潜能得到证实。
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