Falk College of Sport and Human Dynamics, Department of Public Health, Syracuse University, Syracuse, NY, 13244, USA.
Department of Chemistry, State University of New York College at Oswego, Oswego, NY, 13126, USA.
Environ Res. 2023 Apr 15;223:115450. doi: 10.1016/j.envres.2023.115450. Epub 2023 Feb 9.
Air pollution is a serious public health issue with early childhood exposure being of high concern because of the greater risk that children might experience negative health outcomes. Industrial sources in and near communities are one potential path of exposure that children might face with greater levels of air pollution correlating with higher levels of toxicants detected in children. We compare estimated ambient air concentrations of Cadmium (Cd) to a cohort (n = 281) of 9 to 11-year old children during their early childhood years (0-5 years of age) in a mid-size city in Upstate New York. Levels of Cd air pollution are compared to children's urine-Cd levels. Urine has been shown to be a superior biomarker to blood for Cd exposure particularly for longer-term exposures. We find that participants who reside in households that faced greater Cd air pollution during the child's early years have higher urine-Cd levels. This association is stable and stronger than previously presented associations for blood-Cd. Findings support expanded use of air modelling data for risk screening to reduce the potential health burden that industrial pollution can have.
空气污染是一个严重的公共卫生问题,儿童早期暴露尤其令人关注,因为儿童可能面临更大的健康风险。工业污染源在社区内外是儿童可能面临的潜在暴露途径之一,与儿童体内检测到的更高水平的有毒物质相关的更高水平的空气污染与更高水平的空气污染相关。我们将镉(Cd)的估计环境空气浓度与纽约州北部一个中等城市的一个队列(n=281)进行了比较,该队列由 9 至 11 岁的儿童在其幼儿期(0-5 岁)组成。将镉空气污染水平与儿童的尿镉水平进行了比较。尿液已被证明是一种优于血液的 Cd 暴露生物标志物,特别是对于长期暴露。我们发现,在孩子的早期,居住在家庭中面临更大镉空气污染的参与者尿液中的 Cd 水平更高。这种关联是稳定的,比之前呈现的血液-Cd 关联更强。研究结果支持扩大使用空气建模数据进行风险筛查,以减少工业污染可能带来的潜在健康负担。