Groĭsman S D, Gubkin V A, STan E Ia
Biull Eksp Biol Med. 1987 Oct;104(10):423-6.
Two low-molecular peptides, peptide III and peptide IV-1, were isolated from peptic digest of k-casein by Sephadex G-50 and BIO-Gel P-2 chromatography. Intravenous administration of these peptides to dogs at a dose of 0.006 mg/kg inhibited food motility of the stomach and duodenum, but did not change or stimulate fasting motility. The duration of the inhibition was decreased with the diminution of the molecular weight of peptide fractions. Peptide III consisted of two inhibitors. Inhibitor I acted immediately after the injection, while inhibitor 2 acted 60-75 minutes later. Being the natural products of food protein proteolysis, these inhibitors may be apparently used in the clinical practice.
通过葡聚糖凝胶G - 50和BIO - Gel P - 2色谱法从κ-酪蛋白的胃蛋白酶消化物中分离出两种低分子肽，即肽III和肽IV - 1。以0.006mg/kg的剂量给狗静脉注射这些肽，可抑制胃和十二指肠的食物蠕动，但不会改变或刺激空腹蠕动。抑制持续时间随肽组分分子量的减小而缩短。肽III由两种抑制剂组成。抑制剂I在注射后立即起作用，而抑制剂2在60 - 75分钟后起作用。作为食物蛋白水解的天然产物，这些抑制剂显然可用于临床实践。
