Stan E Ia, Zhuravlev B V
Biull Eksp Biol Med. 1986 Dec;102(12):652-5.
Peptide material has been first isolated from k-casein pepsin hydrolysate. Its subcutaneous injection to hungry animals induced high amplitude (250-350 mV) and high frequency (16-20 Hz) oscillations of electrical potentials usually observed in food satiety and cholecystokinin administration. The peptide reduced respiratory and to a lesser extent heart rate. Its effect is temporary eliminated by naloxone. According to an aminogram, the peptide is a fragment of para-k-casein. A neurotropic peptide effect is connected with satiety regulation and milk consumption in the postnatal period.
肽物质最初是从κ-酪蛋白胃蛋白酶水解物中分离出来的。将其皮下注射到饥饿的动物体内，会诱发通常在食物饱腹感和注射胆囊收缩素时观察到的高振幅（250 - 350毫伏）和高频（16 - 20赫兹）的电位振荡。该肽降低了呼吸频率，并在较小程度上降低了心率。其作用可被纳洛酮暂时消除。根据氨基酸分析，该肽是对-κ-酪蛋白的一个片段。一种神经otropic肽效应与产后饱腹感调节和乳汁消耗有关。 （注：原文中“neurotropic”拼写有误，可能是“neurotrophic”，意为“神经营养的”，译文暂按原文翻译）
