Stepanenko E M, Vilkov G A, Kryzhanovskiĭ G N
Biull Eksp Biol Med. 1984 Sep;98(9):336-8.
Lipid peroxidation (LPO) in the brain and blood of guinea-pigs was studied during experimental allergic encephalomyelitis. The most pronounced activation of LPO in the brain occurred at the 7th day of sensitization with encephalolitogenic emulsion. It manifested by an increase in the content of diene conjugates and malonic dialdehyde, activation of catalase and reduction of superoxide dismutase activity. LPO activation in the blood occurred at the 3th-5th day of sensitization. It is assumed that LPO activation is caused by antigen-antibody reaction that occurs in the blood at the 3d day and in the brain at the 7th day of sensitization.
在实验性变应性脑脊髓炎期间，对豚鼠脑和血液中的脂质过氧化（LPO）进行了研究。在用致脑脊髓炎乳剂致敏的第7天，脑中LPO的激活最为明显。其表现为二烯共轭物和丙二醛含量增加、过氧化氢酶激活以及超氧化物歧化酶活性降低。血液中LPO的激活发生在致敏的第3 - 5天。推测LPO的激活是由致敏第3天在血液中以及第7天在脑中发生的抗原 - 抗体反应引起的。
