功能性T细胞在小鼠自身免疫性肾小球肾小管肾病发生过程中的作用
Requirement of functional T-cells in the production of autoimmune glomerulotubular nephropathy in mice.
作者信息
Bolton W K, Benton F R, Lobo P I
出版信息
Clin Exp Immunol. 1978 Sep;33(3):474-7.
Abstract
In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating antibodies to mouse and human kidney and an autoimmune glomerulotubular nephropathy, while the nude mice, even after prolonged immunization, developed neither antibodies nor nephropathy. We therefore concluded that the development of autoimmune glomerulotubular nephropathy in mice requires the presence of functioning T-cells.
摘要
为了研究与自身免疫性肾病产生相关的T细胞功能，我们用弗氏完全佐剂包被的人肾小球免疫随机繁殖小鼠、纯合无胸腺裸鼠（nu/nu）和杂合有毛小鼠（nu/+）。随机繁殖小鼠和杂合有毛小鼠产生了针对小鼠和人肾脏的循环抗体以及一种自身免疫性肾小球肾小管肾病，而裸鼠即使经过长时间免疫，既未产生抗体也未出现肾病。因此，我们得出结论，小鼠自身免疫性肾小球肾小管肾病的发生需要有功能的T细胞存在。
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本文引用的文献
1
Immunological unresponsiveness of genetically thymusless (nude) mice.基因无胸腺（裸）小鼠的免疫无反应性。
Eur J Immunol. 1971 Jan;1(1):59-61. doi: 10.1002/eji.1830010114.
2
Localization of the nephrotoxic antigen within the isolated renal glomerulus.肾毒性抗原在分离出的肾肾小球内的定位。
AMA Arch Pathol. 1951 Jun;51(6):629-39.
3
Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum.用血清转移绵羊实验性过敏性肾小球肾炎（EAG）。
J Exp Med. 1966 Sep 1;124(3):431-42. doi: 10.1084/jem.124.3.431.
4
What are sensitized cells doing in glomerulonephritis?致敏细胞在肾小球肾炎中起什么作用？
N Engl J Med. 1970 Sep 3;283(10):536-7. doi: 10.1056/NEJM197009032831011.
5
6
Experimental glomerulonephritis in the mouse. I. The model.小鼠实验性肾小球肾炎。I. 模型
Clin Exp Immunol. 1971 Nov;9(5):667-76.
7
An immunopathologic study of rapidly progressive glomerulonephritis in the adult.成人快速进展性肾小球肾炎的免疫病理学研究
Hum Pathol. 1971 Jun;2(2):185-208. doi: 10.1016/s0046-8177(71)80034-5.
8
Immunological responses of 'nude' mice.“裸”鼠的免疫反应。
Clin Exp Immunol. 1971 Feb;8(2):305-17.
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In vitro evidence for cellular hypersensitivity to glomerular-basement-membrane antigens in human glomerulonephritis.人类肾小球肾炎中细胞对肾小球基底膜抗原细胞超敏反应的体外证据。
N Engl J Med. 1970 Sep 3;283(10):497-501. doi: 10.1056/NEJM197009032831001.
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