Hénique Carole, Papista Christina, Guyonnet Léa, Lenoir Olivia, Tharaux Pierre-Louis
Paris Cardiovascular Centre - PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.
Semin Immunopathol. 2014 Jul;36(4):479-90. doi: 10.1007/s00281-014-0435-7. Epub 2014 Jun 20.
The recent years have seen a number of major progresses in the field of extracapillary glomerulonephritis. This entity is the final damage caused by unrelated immunological disorders such as immune complexes glomerular deposits or microvascular injury caused by proinflammatory cytokines, neutrophil extracellular traps (NET), and cell adhesion molecules in the context of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This review provides a summary of recent advances in the understanding of crescentic glomerulonephritis, focusing on interplays of local immune cells and on local mediators participating to crescent formation especially in anti-glomerular basement membrane (anti-GBM) antibody disease. The recent advances about AAV and lupus nephritis are covered by other chapters of this issue. Nevertheless, these considerations may apply to the general case of crescentic glomerulonephritis of all causes.
近年来，毛细血管外肾小球肾炎领域取得了一些重大进展。该实体是由不相关的免疫紊乱引起的最终损害，如免疫复合物肾小球沉积或在抗中性粒细胞胞浆抗体（ANCA）相关血管炎（AAV）背景下由促炎细胞因子、中性粒细胞胞外陷阱（NET）和细胞粘附分子引起的微血管损伤。本综述总结了在新月体性肾小球肾炎认识方面的最新进展，重点关注局部免疫细胞的相互作用以及参与新月体形成的局部介质，特别是在抗肾小球基底膜（anti-GBM）抗体疾病中。本期的其他章节涵盖了AAV和狼疮性肾炎的最新进展。然而，这些考量可能适用于所有病因的新月体性肾小球肾炎的一般情况。
