Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.
BMC Womens Health. 2023 Feb 10;23(1):57. doi: 10.1186/s12905-023-02182-w.
Cellular angiofibroma (CA) is a rare, benign mesenchymal tumor first described by Nucci et al. (Am J Surg Pathol 21:636-644, 1997. 10.1097/00000478-199706000-00002). It affects both men and women, although it is more common in middle-aged women. CA is well circumscribed and usually observed on the body surface, primarily in distal genital regions. Aggressive angiomyxoma and angiomyofibroblastoma are clinically and histologically similar; therefore, it may be necessary to distinguish between CA and these similar tumors. We present a rare case of CA, with atypical features, in the retroperitoneal space during pregnancy.
The presence of a 130 mm tumor was detected in a 19-year-old woman. The tumor, located in the retroperitoneal space, was found during first pregnancy examination. At 16 weeks of gestation, the woman developed nausea and fever, and it was diagnosed with acute pyelonephritis. After a few days, the amniotic membranes prematurely ruptured, leading to a miscarriage. The woman underwent a tumor resection, after miscarriage. This case presented with atypical features of CA. This included the young age of the patient, and presence of a tumor in the retroperitoneal space.
In this case, the diagnosis of CA was difficult due to the rarity of the disease and its atypical clinical features. From this experience, we recommend that the discussion on the efficacy of surgical treatment and pregnancy outcomes should be done based on individual case, and not generalized.
细胞血管纤维瘤（CA）是一种罕见的良性间叶性肿瘤，最初由 Nucci 等人描述。（Am J Surg Pathol 21:636-644, 1997. 10.1097/00000478-199706000-00002）。它影响男性和女性，尽管它在中年女性中更为常见。CA 边界清楚，通常发生在体表，主要发生在远端生殖器区域。侵袭性血管黏液瘤和血管肌纤维母细胞瘤在临床和组织学上相似；因此，有必要区分 CA 和这些相似的肿瘤。我们报告了一例罕见的 CA 病例，其特征不典型，发生在妊娠期间的腹膜后间隙。
一名 19 岁女性发现一个 130 毫米的肿瘤。肿瘤位于腹膜后间隙，是在第一次妊娠检查时发现的。妊娠 16 周时，该女性出现恶心和发热，被诊断为急性肾盂肾炎。几天后，胎膜过早破裂，导致流产。该女性在流产后接受了肿瘤切除术。该病例具有 CA 的不典型特征。这包括患者年龄较小，以及腹膜后间隙存在肿瘤。
在本例中，由于疾病罕见且临床表现不典型，CA 的诊断较为困难。从这一经验中，我们建议应根据个体病例讨论手术治疗的效果和妊娠结局，而不是一概而论。
