Schoolmeester John K, Fritchie Karen J
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
J Cutan Pathol. 2015 Jul;42(7):441-51. doi: 10.1111/cup.12507. Epub 2015 May 21.
Mesenchymal neoplasms of the vulvovaginal and inguinoscrotal regions are among the most diagnostically challenging specimens in the pathology laboratory owing largely to their unique intersection between general soft tissue tumors and relatively genital-specific mesenchymal tumors. Genital stromal tumors are a unique subset of soft tissue tumors encountered at this location, and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma and aggressive angiomyxoma. Aside from the striking morphologic and immunophenotypic similarity that is seen with these entities, there is evidence that a subset of genital stromal tumors may be linked genetically. This review will focus on simplifying this group of tumors and provide the pathologist or dermatopathologist with practical management information. Smooth muscle tumors of the external genitalia will also be discussed.
外阴阴道和腹股沟阴囊区域的间叶性肿瘤是病理实验室中诊断最具挑战性的标本之一，这主要是因为它们处于一般软组织肿瘤和相对特定于生殖器的间叶性肿瘤的独特交叉点。生殖器间质肿瘤是在此部位遇到的软组织肿瘤的一个独特子集，这一组包括纤维上皮性间质息肉、浅表（宫颈阴道）肌成纤维细胞瘤、细胞性血管纤维瘤、乳腺型肌成纤维细胞瘤、血管肌成纤维细胞瘤和侵袭性血管黏液瘤。除了这些实体之间明显的形态学和免疫表型相似性外，有证据表明一部分生殖器间质肿瘤可能存在遗传联系。本综述将着重简化这组肿瘤，并为病理学家或皮肤病理学家提供实用的管理信息。还将讨论外生殖器的平滑肌瘤。
