Jiang Wenqi, Liang Mingkang, Lei Qifang, Li Guangzhi, Wu Song
The Affiliated Luohu Hospital of Shenzhen University, School of Basic Medical Science, Health Science Center, Shenzhen University, Shenzhen 518000, China.
Luohu Clinical Institute of Shantou University Medical College, Shantou University Medical College, Shantou University, Shantou 515000, China.
Cancers (Basel). 2023 Jan 18;15(3):585. doi: 10.3390/cancers15030585.
Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic therapy (PDT), a non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance in cancer therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well as oxygen dependence, largely limit its therapeutic efficiency for solid tumors treatment. Thus, numerous strategies have gone into overcoming these obstacles, such as exploring new photosensitizers with higher photodynamic conversion efficiency, alleviating tumor hypoxia to fuel the generation of reactive oxygen species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, we briefly summarized the PDT related tumor therapeutic approaches, which are mainly characterized by advanced PSs, these PSs have excellent conversion efficiency and additional refreshing features. We also briefly summarize PDT-based combination therapies with excellent therapeutic effects.
尽管多年来我们在治疗致命疾病方面取得了巨大进展，但癌症治疗仍然是一项艰巨的挑战。在众多抗癌方法中，光动力疗法（PDT）作为一种非侵入性治疗方法，备受关注。PDT在癌症治疗中表现出色，但一些不可避免的缺点，包括光穿透深度有限、肿瘤选择性差以及对氧气的依赖性，在很大程度上限制了其对实体瘤的治疗效果。因此，人们采取了许多策略来克服这些障碍，例如探索具有更高光动力转换效率的新型光敏剂、缓解肿瘤缺氧以促进活性氧（ROS）的产生、设计肿瘤靶向性光敏剂以及应用基于PDT的联合策略。在这篇综述中，我们简要总结了与PDT相关的肿瘤治疗方法，这些方法主要以先进的光敏剂为特征，这些光敏剂具有出色的转换效率和其他新颖特性。我们还简要总结了具有优异治疗效果的基于PDT的联合疗法。
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