Papadomichelakis George, Palamidi Irida, Paraskeuas Vasileios V, Giamouri Elisavet, Mountzouris Konstantinos C
Laboratory of Nutritional Physiology and Feeding, Department of Animal Science, Agricultural University of Athens, 118 55 Athens, Greece.
Animals (Basel). 2023 Jan 27;13(3):431. doi: 10.3390/ani13030431.
A natural phytogenic formulation (NPF) was tested as an alternative to pharmaceutical zinc oxide (ZnO) in weaned piglets with respect to growth performance, apparent total tract digestibility and faecal microbiota composition and metabolic activity. Two dietary NPF levels (NPF: 1000 and 2000 mg/kg diet) were compared to a positive control (ZnO: 3000 mg ZnO/kg diet) and a negative control (CON: no added ZnO or NPF) using 84 weaned piglets from 29 d to 78 d (days of age). Feed conversion ratio was improved ( < 0.05) in ZnO and NPF piglets were compared to CON at 50 d. Dry matter, organic matter and crude protein ( < 0.05) digestibility was improved in NPF piglets compared to CON at 57 d. Compared to CON, NPF inclusion reduced ( < 0.05) and increased subgroup ( < 0.01) at 57 d and 78 d, and reduced subgroup ( < 0.05; at 78 d). The ZnO reduced ( < 0.001) and subgroup ( < 0.01) compared to CON at 78 d. Moreover, ZnO and NPF reduced molar ratios of branched chain volatile fatty acids ( < 0.05) compared to CON, while NPF also increased butyric acid ( < 0.05) at 78 d. In conclusion, the NPF appeared to be a promising alternative to pharmaceutical doses of ZnO.
在断奶仔猪中，对一种天然植物源制剂（NPF）作为药用氧化锌（ZnO）的替代品进行了测试，比较其在生长性能、表观全肠道消化率、粪便微生物群组成和代谢活性方面的效果。使用84头29日龄至78日龄的断奶仔猪，将两种日粮NPF水平（NPF：1000和2000 mg/kg日粮）与阳性对照（ZnO：3000 mg ZnO/kg日粮）和阴性对照（CON：不添加ZnO或NPF）进行比较。在50日龄时，与CON组相比，ZnO组和NPF组仔猪的饲料转化率得到改善（P<0.05）。在57日龄时，与CON组相比，NPF组仔猪的干物质、有机物和粗蛋白消化率得到改善（P<0.05）。与CON组相比，在57日龄和78日龄时，添加NPF降低了（P<0.05）[具体菌群名称未给出]并增加了[具体菌群名称未给出]亚组（P<0.01），在78日龄时降低了[具体菌群名称未给出]亚组（P<0.05）。在78日龄时，与CON组相比，ZnO降低了（P<0.001）[具体菌群名称未给出]和[具体菌群名称未给出]亚组（P<0.01）。此外，与CON组相比，ZnO和NPF降低了支链挥发性脂肪酸的摩尔比（P<0.05），而在78日龄时，NPF还增加了丁酸含量（P<0.05）。总之，NPF似乎是药用剂量ZnO的一种有前景的替代品。
