Nassar Farid S, Alsahlawi Abdulaziz M, Abdellatif Hasan A E, Kamel Nancy N, Abbas Ahmed O
Department of Animal and Fish Production, College of Agricultural and Food Sciences, King Faisal University, P.O. Box 420, Al-Ahsa 31982, Saudi Arabia.
Department of Animal Production, Faculty of Agriculture, Cairo University, P.O. Box 12613, Giza 12613, Egypt.
Animals (Basel). 2023 Jan 28;13(3):441. doi: 10.3390/ani13030441.
Immunosuppression is a serious consequence of oxidative stress exposure that negatively affects the productivity and profitability of birds, as well as their well-being. Thus, the present investigation was designed to evaluate the potential of corn silk extract (CSE) supplementation to overcome the negative impacts of oxidative stress induced by corticosterone administration (CORT) in broiler chickens. A total of 280 one day old Cobb 500 male chicks were divided into four groups in 2 × 2 factorial arrangements. The experimental groups included CSE supplementation (0 or 500 mg/kg diet, from 20 to 35 days of age) and CORT administration (0 or 25 mg/kg diet, from 22 to 35 days of age) as independent factors. At the end of week five of age, production performance parameters were measured. The humoral and cell-mediated immune response parameters, redox status, and stress markers were determined. Data revealed deleterious effects of CORT administration on the broilers' body weight, body weight gain, and feed conversion ratio. Moreover, an exponential increase in stress marker levels, in addition to immunosuppression and redox imbalance, were associated with CORT administration. However, CSE supplementation, with its high total phenols content, partially alleviated the negative impacts of CORT administration, as shown by a significant improvement in immune response parameters and antioxidant activity, as well as a reduction in stress marker levels. Furthermore, CSE supplementation to non-stressed birds even significantly improved total antioxidant activity, total white blood cells (TWBCs) count, T-lymphocyte stimulating index, and wattle thickness. It can be concluded that, under stress conditions in commercial broiler farms, dietary CSE supplementation can strongly be recommended to modulate the negative impacts of stress. Therefore, CSE can be used as an effective immunomodulator and antioxidant agent to increase commercial broiler farm productivity and profitability.
免疫抑制是氧化应激暴露的严重后果，会对禽类的生产性能、盈利能力及其健康产生负面影响。因此，本研究旨在评估补充玉米须提取物（CSE）以克服皮质酮给药（CORT）诱导的氧化应激对肉鸡的负面影响的潜力。总共280只1日龄的科宝500雄性雏鸡按2×2析因设计分为四组。实验组将补充CSE（0或500毫克/千克日粮，从20至35日龄）和给予CORT（0或25毫克/千克日粮，从22至35日龄）作为独立因素。在5周龄结束时，测量生产性能参数。测定体液和细胞介导的免疫反应参数、氧化还原状态和应激标志物。数据显示，给予CORT对肉鸡的体重、体重增加和饲料转化率有有害影响。此外，应激标志物水平呈指数增加，同时伴有免疫抑制和氧化还原失衡，这与给予CORT有关。然而，CSE因其高总酚含量，部分减轻了给予CORT的负面影响，免疫反应参数和抗氧化活性显著改善以及应激标志物水平降低表明了这一点。此外，向未受应激的禽类补充CSE甚至显著提高了总抗氧化活性、总白细胞（TWBCs）计数、T淋巴细胞刺激指数和肉髯厚度。可以得出结论，在商业肉鸡场的应激条件下，强烈建议在日粮中补充CSE以调节应激的负面影响。因此，CSE可作为一种有效的免疫调节剂和抗氧化剂，以提高商业肉鸡场的生产力和盈利能力。
