Instituto de Investigación Sanitaria de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía da Choupana s/n, 15706 Santiago de Compostela, Spain.
CIBER de Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III, 15706 Santiago de Compostela, Spain.
Int J Mol Sci. 2022 Nov 1;23(21):13318. doi: 10.3390/ijms232113318.
Fibroblast growth factor 21 is a pleiotropic hormone secreted mainly by the liver in response to metabolic and nutritional challenges. Physiologically, fibroblast growth factor 21 plays a key role in mediating the metabolic responses to fasting or starvation and acts as an important regulator of energy homeostasis, glucose and lipid metabolism, and insulin sensitivity, in part by its direct action on the central nervous system. Accordingly, pharmacological recombinant fibroblast growth factor 21 therapies have been shown to counteract obesity and its related metabolic disorders in both rodents and nonhuman primates. In this systematic review, we discuss how fibroblast growth factor 21 regulates metabolism and its interactions with the central nervous system. In addition, we also state our vision for possible therapeutic uses of this hepatic-brain axis.
成纤维细胞生长因子 21 是一种多功能激素，主要由肝脏在代谢和营养挑战时分泌。从生理学上讲，成纤维细胞生长因子 21 在介导对禁食或饥饿的代谢反应方面发挥着关键作用，并作为能量平衡、葡萄糖和脂质代谢以及胰岛素敏感性的重要调节剂，部分通过其对中枢神经系统的直接作用。因此，药理学重组成纤维细胞生长因子 21 疗法已被证明可在啮齿动物和非人类灵长类动物中对抗肥胖及其相关代谢紊乱。在本系统评价中，我们讨论了成纤维细胞生长因子 21 如何调节代谢及其与中枢神经系统的相互作用。此外，我们还阐述了该肝脑轴可能的治疗用途的展望。
