通过靶向 mA-YTHDF2 依赖的方式调控 Rex 兔肌肉内脂肪基因。
Regulated Intramuscular Fat by Targeting Gene via an mA-YTHDF2-dependent Manner in Rex Rabbits.
机构信息
College of Animal Science and Technology, Northwest A & F University, Xianyang 712100, China.
出版信息
Cells. 2023 Jan 19;12(3):369. doi: 10.3390/cells12030369.
N6-methyladenosine (mA) regulates fat development in many ways. Low intramuscular fat (IMF) in rabbit meat seriously affects consumption. In order to improve meat quality, we explored the law of IMF deposition. could increase the expression of and adipocyte differentiation through methylation. However, interference can partially recover the influence of interference on the gene and adipocyte differentiation. promoted the differentiation of adipocytes. Analysis of IMF and expression showed IMF content is positive with the expression level of the gene ( < 0.01). Conclusion: Together, can regulate intramuscular fat by targeting the gene via an mA-YTHDF2-dependent manner in Rex rabbits. The result provides a theoretical basis for the molecular breeding of rabbits.
N6-甲基腺苷（mA）通过多种方式调节脂肪发育。兔肉中低肌内脂肪（IMF）严重影响消费。为了改善肉质，我们探讨了 IMF 沉积的规律。通过甲基化可以增加 和脂肪细胞分化的表达。然而，干扰 可以部分恢复干扰 对 基因和脂肪细胞分化的影响。促进脂肪细胞的分化。对 IMF 和 表达的分析表明，IMF 含量与 基因的表达水平呈正相关（<0.01）。结论：总之，在 Rex 兔中， 通过 mA-YTHDF2 依赖的方式靶向 基因可以调节肌内脂肪。该结果为兔的分子育种提供了理论基础。
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