慢性肾脏病（CKD）中自体荧光晚期糖基化终产物（AGEs）与虚弱成分的相关性：来自单中心队列研究的数据。

Association of Autofluorescent Advanced Glycation End Products (AGEs) with Frailty Components in Chronic Kidney Disease (CKD): Data from a Single-Center Cohort Study.

机构信息

Unit of Nephrology, Dialysis and Kidney Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.

Laboratory of Clinical Pathology, Department of Biomedical Science for Health, Università degli Studi di Milano, 20133 Milan, Italy.

出版信息

Cells. 2023 Jan 29;12(3):438. doi: 10.3390/cells12030438.

DOI:10.3390/cells12030438

PMID:36766780

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9913604/

Abstract

BACKGROUND

Chronic kidney disease (CKD) is characterized by an overproduction and accumulation of advanced glycation end products (AGEs). Because AGEs may play a role in the development of malnutrition and sarcopenia, two essential components of frailty, we evaluated whether they may also contribute to the onset of frailty in CKD patients.

METHODS

We performed a cross-sectional analysis of 117 patients. AGEs were quantified using a fluorescence spectrophotometer and soluble receptor for AGE (sRAGE) isoforms by ELISA. We defined frailty according to the frailty phenotype (FP) proposed by Fried.

RESULTS

The average age of patients was 80 ± 11 years, 70% were male, and the mean eGFR was 25 + 11 mL/min/1.73m. Frailty was diagnosed in 51 patients, and 40 patients were classified as pre-frail. AGEs and RAGE isoforms seem not to correlate with overall frailty. Instead, AGEs were associated with specific frailty domains, inversely associated with BMI (R = -0.22, = 0.016) and directly associated with gait test time (R = 0.17, = 0.049). AGEs were also associated with involuntary weight loss (OR 1.84 = 0.027), independent of age and sex.

CONCLUSIONS

AGEs are associated with some pivotal components of the frailty phenotype, although they are not associated with frailty overall.

摘要

背景

慢性肾脏病（CKD）的特征是晚期糖基化终产物（AGEs）的过度产生和积累。由于 AGEs 可能在营养不良和肌肉减少症（衰弱的两个重要组成部分）的发展中起作用，我们评估了它们是否也可能导致 CKD 患者衰弱的发生。

方法

我们对 117 例患者进行了横断面分析。使用荧光分光光度计和 ELISA 测定 AGEs 和可溶性 AGE 受体（sRAGE）同工型。我们根据 Fried 提出的衰弱表型（FP）定义衰弱。

结果

患者的平均年龄为 80 ± 11 岁，70%为男性，平均 eGFR 为 25 ± 11 mL/min/1.73m。51 例患者被诊断为衰弱，40 例患者被归类为衰弱前期。AGEs 和 RAGE 同工型似乎与整体衰弱无关。相反，AGEs 与特定的衰弱域相关，与 BMI 呈负相关（R = -0.22， = 0.016），与步态测试时间呈正相关（R = 0.17， = 0.049）。AGEs 还与非自愿性体重减轻（OR 1.84 = 0.027）相关，与年龄和性别无关。