骨密度与口腔功能衰退对肾功能的关联：志贺研究的结果

Association between Bone Mineral Density and Oral Frailty on Renal Function: Findings from the Shika Study.

作者信息

Nakai Shingo, Suzuki Fumihiko, Okamoto Shigefumi, Miyagi Sakae, Tsujiguchi Hiromasa, Hara Akinori, Nguyen Thao Thi Thu, Shimizu Yukari, Hayashi Koichiro, Suzuki Keita, Kasahara Tomoko, Nakamura Masaharu, Takazawa Chie, Kannon Takayuki, Tajima Atsushi, Tsuboi Hirohito, Ogino Noriyoshi, Konoshita Tadashi, Takamura Toshinari, Nakamura Hiroyuki

机构信息

Department of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Japan.

Department of Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa 920-8640, Japan.

出版信息

Healthcare (Basel). 2023 Jan 20;11(3):314. doi: 10.3390/healthcare11030314.

DOI:10.3390/healthcare11030314

PMID:36766889

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9913924/

Abstract

The association between oral frailty (OFr) and body action has been investigated, but its association with systemic function remains unclear. Therefore, this cross-sectional study examined the association between OFr with decreased bone mineral density (BMD) and renal function in residents of Shika town, Ishikawa Prefecture, Japan aged ≥40 years. This study included 400 inhabitants. The OFr total score was assessed using three oral domains in the Kihon Checklist (a self-reported comprehensive health checklist), the number of teeth, and brushing frequency per day. Measurements were the estimated glomerular filtration rate (eGFR) and the osteo-sono assessment index (OSI). Using a two-way analysis of covariance ( = 0.002), significantly lower OSI was indicated in the eGFR < 60 and OFr group than in the eGFR of < 60 and non-OFr group after adjusting for age, body mass index, and drinking and smoking status as confounding factors. Multiple logistic regression analysis confirmed this relationship ( = 0.006). Therefore, lower BMD seems to be associated with lower renal function only when accompanied by OFr. Further longitudinal studies are needed to confirm these results.

摘要

口腔脆弱（OFr）与身体活动之间的关联已得到研究，但其与全身功能的关联仍不明确。因此，这项横断面研究调查了日本石川县鹿贺町年龄≥40岁居民中OFr与骨密度（BMD）降低及肾功能之间的关联。该研究纳入了400名居民。使用基本检查表（一份自我报告的综合健康检查表）中的三个口腔领域、牙齿数量和每日刷牙频率来评估OFr总分。测量指标为估计肾小球滤过率（eGFR）和骨声评估指数（OSI）。在将年龄、体重指数以及饮酒和吸烟状况作为混杂因素进行校正后，采用双向协方差分析（=0.002）表明，eGFR<60且存在OFr的组中OSI显著低于eGFR<60且不存在OFr的组。多元逻辑回归分析证实了这种关系（=0.006）。因此，似乎只有在伴有OFr时，较低的骨密度才与较低的肾功能相关。需要进一步的纵向研究来证实这些结果。