• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

保加利亚的宫颈癌：一场危机的流行病学

Cancer of the Cervix in Bulgaria: Epidemiology of a Crisis.

作者信息

Yordanov Angel, Vasileva-Slaveva Mariela, Galai Noya, Faraggi David, Kubelac Milan Paul, Tripac-Iacovleva Irina, Calleja Neville, Di Fiore Riccardo, Calleja-Agius Jean

机构信息

Department of Gynecological Oncology, Medical Universiy Pleven, 5800 Pleven, Bulgaria.

Department of Breast Surgery, "Dr. Shterev" Hospital, 1330 Sofia, Bulgaria.

出版信息

Healthcare (Basel). 2023 Jan 20;11(3):318. doi: 10.3390/healthcare11030318.

DOI:10.3390/healthcare11030318
PMID:36766893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9914859/
Abstract

UNLABELLED

Eastern Europe continues to have the highest rates of cancer of the uterine cervix (CUC) and human papillomavirus (HPV) infection in Europe.

AIM

The aim of this study was to investigate CUC trends in Bulgaria in the context of a lack of a population-based screening program and a demographic crisis.

METHODOLOGY

This was a retrospective study of 7861 CUC patients who were registered in the Bulgarian National Cancer Registry (BNCR) between 2013 and 2020 and followed up with until March 2022. We used descriptive statistics and modeling to assess temporal trends in new CUC incidence rates and identify factors associated with survival.

RESULTS

Bulgaria's population has decreased by 11.5% between 2011 and 2021. The CUC incidence rate decreased from 29.5/100,000 in 2013 to 23.2/100,000 in 2020 but remains very high. The proportion of patients diagnosed in earlier stages of CUC has decreased over time. Up to 19% of patients with CUC in Bulgaria are diagnosed between the age of 35 and 44 years. The median survival was 101.5 months, with some improvement in later years (adjusted HR = 0.83 for 2017-2020).

CONCLUSIONS

In countries with well-established population-based screening, CUC is nowadays considered a rare disease. However, it is not considered rare in Bulgaria. Population-based screening starting at an earlier age is the fastest way to improve outcomes.

摘要

未标注

在欧洲，东欧的子宫颈癌（CUC）和人乳头瘤病毒（HPV）感染率仍然最高。

目的

本研究的目的是在缺乏基于人群的筛查计划和人口危机的背景下，调查保加利亚的子宫颈癌趋势。

方法

这是一项回顾性研究，对2013年至2020年在保加利亚国家癌症登记处（BNCR）登记并随访至2022年3月的7861例子宫颈癌患者进行了研究。我们使用描述性统计和建模来评估子宫颈癌新发病率的时间趋势，并确定与生存相关的因素。

结果

2011年至2021年期间，保加利亚人口减少了11.5%。子宫颈癌发病率从2013年的29.5/10万降至2020年的23.2/10万，但仍然很高。随着时间的推移，在子宫颈癌早期阶段被诊断出的患者比例有所下降。保加利亚高达19%的子宫颈癌患者是在35至44岁之间被诊断出来的。中位生存期为101.5个月，后期有所改善（2017 - 2020年调整后风险比 = 0.83）。

结论

在拥有完善的基于人群筛查的国家，如今子宫颈癌被认为是一种罕见疾病。然而，在保加利亚并非如此。尽早开始基于人群的筛查是改善治疗效果的最快途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/958a69b13c7a/healthcare-11-00318-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/3b55482d4dfa/healthcare-11-00318-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/c67c7c9e976c/healthcare-11-00318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/ff59588b9252/healthcare-11-00318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/49f3e782d76b/healthcare-11-00318-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/5f26498ece01/healthcare-11-00318-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/3b1993cebcdf/healthcare-11-00318-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/1ca64c2c7a64/healthcare-11-00318-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/958a69b13c7a/healthcare-11-00318-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/3b55482d4dfa/healthcare-11-00318-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/c67c7c9e976c/healthcare-11-00318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/ff59588b9252/healthcare-11-00318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/49f3e782d76b/healthcare-11-00318-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/5f26498ece01/healthcare-11-00318-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/3b1993cebcdf/healthcare-11-00318-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/1ca64c2c7a64/healthcare-11-00318-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f143/9914859/958a69b13c7a/healthcare-11-00318-g008.jpg

相似文献

1
Cancer of the Cervix in Bulgaria: Epidemiology of a Crisis.保加利亚的宫颈癌：一场危机的流行病学
Healthcare (Basel). 2023 Jan 20;11(3):318. doi: 10.3390/healthcare11030318.
2
Temporal changes in the cervical cancer burden in Bulgaria: Implications for eastern european countries going through transition.保加利亚宫颈癌负担的时间变化：对正在经历转型的东欧国家的启示。
Cancer Epidemiol. 2016 Oct;44:154-160. doi: 10.1016/j.canep.2016.08.014. Epub 2016 Sep 3.
3
Bulgaria.保加利亚。
Backgr Notes Ser. 1983 Apr:1-7.
4
Adenosquamous Carcinoma of the Uterine Cervix - Impact of Histology on Clinical Management.子宫颈腺鳞癌——组织学对临床管理的影响
Cancer Manag Res. 2021 Jun 23;13:4979-4986. doi: 10.2147/CMAR.S311326. eCollection 2021.
5
Patterns and trends in human papillomavirus-related diseases in Central and Eastern Europe and Central Asia.中东北欧和中亚地区人乳头瘤病毒相关疾病的模式和趋势。
Vaccine. 2013 Dec 31;31 Suppl 7:H32-45. doi: 10.1016/j.vaccine.2013.02.071.
6
Endometrial carcinoma in patients under 40 years of age: insights from the Bulgarian Cancer Registry.40 岁以下子宫内膜癌患者：来自保加利亚癌症登记处的见解。
Ginekol Pol. 2023;94(4):275-282. doi: 10.5603/GP.a2022.0106.
7
Eastern Europe: pronatalist policies and private behavior.东欧：鼓励生育政策与个人行为
Popul Bull. 1982 Feb;36(6):1-49.
8
Thyroid Cancer Incidence in Bulgaria before and after the Introduction of Universal Salt Iodization: An Analysis of the National Cancer Registry Data.保加利亚全民食盐碘化前后甲状腺癌发病率的变化：国家癌症登记数据分析。
Balkan Med J. 2020 Oct 23;37(6):330-335. doi: 10.4274/balkanmedj.galenos.2020.2019.10.5. Epub 2020 Aug 28.
9
Cancer burden of breast and gynecological cancers in Bulgaria: epidemiology and clinical aspects.保加利亚乳腺癌和妇科癌症的癌症负担：流行病学与临床方面
J BUON. 2013 Oct-Dec;18(4):1038-44.
10
[Natural increase of Bulgaria's population].
Geogr Cas. 1976;25(9):1-5.

引用本文的文献

1
Revisiting Querleu-Morrow Radical Hysterectomy: How to Apply the Anatomy of Parametrium and Pelvic Autonomic Nerves to Cervical Cancer Surgery?重温奎勒-莫罗根治性子宫切除术：如何将宫旁组织和盆腔自主神经的解剖结构应用于宫颈癌手术？
Cancers (Basel). 2024 Jul 31;16(15):2729. doi: 10.3390/cancers16152729.

本文引用的文献

1
Cervical cancer screening guidelines and screening practices in 11 countries: A systematic literature review.11个国家的宫颈癌筛查指南与筛查实践：一项系统文献综述
Prev Med Rep. 2022 May 8;28:101813. doi: 10.1016/j.pmedr.2022.101813. eCollection 2022 Aug.
2
Human papillomavirus vaccination in the European Union/European Economic Area and globally: a moral dilemma.人乳头瘤病毒疫苗接种在欧盟/欧洲经济区和全球范围内：一个道德困境。
Euro Surveill. 2021 Dec;26(50). doi: 10.2807/1560-7917.ES.2021.26.50.2001659.
3
Estimate of global human papillomavirus vaccination coverage: analysis of country-level indicators.
全球人乳头瘤病毒疫苗接种覆盖率的估计：国家层面指标分析。
BMJ Open. 2021 Sep 2;11(9):e052016. doi: 10.1136/bmjopen-2021-052016.
4
Updated evidence-based recommendations for cervical cancer screening in France.法国更新的宫颈癌筛查循证推荐建议。
Eur J Cancer Prev. 2022 May 1;31(3):279-286. doi: 10.1097/CEJ.0000000000000701.
5
Addressing disparities and challenges in underserved patient populations with metastatic breast cancer in Europe.解决欧洲转移性乳腺癌服务不足患者群体中的差异和挑战。
Breast. 2021 Feb;55:79-90. doi: 10.1016/j.breast.2020.12.005. Epub 2020 Dec 13.
6
Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.2018 年宫颈癌发病率和死亡率的估计：全球分析。
Lancet Glob Health. 2020 Feb;8(2):e191-e203. doi: 10.1016/S2214-109X(19)30482-6. Epub 2019 Dec 4.
7
Evaluation of Cervical Intraepithelial Neoplasia Occurrence Following the Recorded Onset of Persistent High-Risk Human Papillomavirus Infection: A Retrospective Study on Infection Duration.持续性高危型人乳头瘤病毒感染确诊后宫颈上皮内瘤变发生情况的评估：一项关于感染持续时间的回顾性研究
Front Oncol. 2019 Oct 1;9:976. doi: 10.3389/fonc.2019.00976. eCollection 2019.
8
Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries, 2020-99: a modelling study.在 181 个国家/地区扩大人乳头瘤病毒疫苗接种和宫颈癌筛查的影响，以及在 2020-99 年全球消除宫颈癌的可能性：一项建模研究。
Lancet Oncol. 2019 Mar;20(3):394-407. doi: 10.1016/S1470-2045(18)30836-2. Epub 2019 Feb 19.
9
Involvement of Human Papillomaviruses in Cervical Cancer.人乳头瘤病毒与宫颈癌的关系
Front Microbiol. 2018 Nov 28;9:2896. doi: 10.3389/fmicb.2018.02896. eCollection 2018.
10
Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries.全球癌症生存趋势监测 2000-14 年（CONCORD-3）：对来自 71 个国家 322 个基于人群的登记处的 37513025 名诊断患有 18 种癌症之一的患者的个体记录进行分析。
Lancet. 2018 Mar 17;391(10125):1023-1075. doi: 10.1016/S0140-6736(17)33326-3. Epub 2018 Jan 31.