Wang Wei, Arcà Emanuele, Sinha Anushua, Hartl Kristina, Houwing Natalie, Kothari Smita
Merck Sharp & Dohme Corp., United States.
OPEN Health, Netherlands.
Prev Med Rep. 2022 May 8;28:101813. doi: 10.1016/j.pmedr.2022.101813. eCollection 2022 Aug.
The World Health Organization (WHO) advocates population-based screening programs to reduce the global incidence of cervical cancer. However, screening guidelines and practice continually change to reflect scientific developments. Here we describe and compare cervical cancer screening guidelines and clinical practice in 11 countries across North America, Europe, and Asia-Pacific. We conducted a systematic literature review (SLR) complemented by a targeted literature review (TLR) to identify relevant peer-reviewed publications and policy documents, which include 120 publications, of which 86 were identified from the SLR and 34 from the TLR. Only six of 11 countries assessed have population-based screening programs in place. Considerable differences persist across countries' screening guidelines, even among comparable systems. Moreover, methods of data collection are also heterogenous, and systematic data collection is often not established. As future changes in screening guidelines and clinical practice occur (e.g., when the first cohorts of women vaccinated against HPV reach screening age), systematic collection of screening data is essential to monitor and improve screening performance.
世界卫生组织（WHO）倡导开展基于人群的筛查项目，以降低全球宫颈癌发病率。然而，筛查指南和实践不断变化，以反映科学进展。在此，我们描述并比较了北美、欧洲和亚太地区11个国家的宫颈癌筛查指南及临床实践。我们进行了一项系统文献综述（SLR），并辅以定向文献综述（TLR），以确定相关的同行评审出版物和政策文件，共包括120篇出版物，其中86篇通过SLR确定，34篇通过TLR确定。在评估的11个国家中，只有6个国家实施了基于人群的筛查项目。各国的筛查指南之间仍然存在相当大的差异，即使在类似的体系中也是如此。此外，数据收集方法也各不相同，而且往往没有建立系统的数据收集机制。随着筛查指南和临床实践未来的变化（例如，当首批接种HPV疫苗的女性群体达到筛查年龄时），系统收集筛查数据对于监测和提高筛查效果至关重要。
