1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland.
Int J Mol Sci. 2023 Jan 17;24(3):1852. doi: 10.3390/ijms24031852.
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. To date, a lot of research has been conducted to investigate the underlying mechanisms of this disease at both molecular and cellular levels. There is increasing evidence suggesting that autoimmunity is an important factor in the initiation and perpetuation of AF. Autoantibodies are thought to play a pivotal role in the regulation of heart rhythm and the conduction system and, therefore, are associated with AF development. In this review, we have summarized current knowledge concerning the role of autoantibodies in AF development as well as their prognostic and predictive value in this disease. The establishment of the autoantibody profile of separate AF patient groups may appear to be crucial in terms of developing novel treatment approaches for those patients; however, the exact role of various autoantibodies in AF is still a matter of ongoing debate.
心房颤动（AF）是最常见的心律失常类型。迄今为止，已经进行了大量的研究来探究这种疾病在分子和细胞水平上的潜在机制。越来越多的证据表明，自身免疫是 AF 发生和持续的重要因素。自身抗体被认为在调节心率和传导系统中起着关键作用，因此与 AF 的发生有关。在这篇综述中，我们总结了目前关于自身抗体在 AF 发生中的作用以及它们在该疾病中的预后和预测价值的知识。确定不同 AF 患者群体的自身抗体谱似乎对于为这些患者开发新的治疗方法至关重要；然而，各种自身抗体在 AF 中的确切作用仍在争论之中。
