Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Turin, Italy.
Int J Mol Sci. 2023 Jan 23;24(3):2262. doi: 10.3390/ijms24032262.
Splanchnic vein thrombosis is a rare but potentially life-threatening manifestation of venous thromboembolism, with challenging implications both at the pathological and therapeutic level. It is frequently associated with liver cirrhosis, but it could also be provoked by myeloproliferative disorders, cancer of various gastroenterological origin, abdominal infections and thrombophilia. A portion of splanchnic vein thrombosis is still classified as idiopathic. Here, we review the mechanisms of splanchnic vein thrombosis, including new insights on the role of clonal hematopoiesis in idiopathic SVT pathogenesis, with important implications from the therapeutic standpoint.
内脏静脉血栓形成是一种罕见但可能危及生命的静脉血栓栓塞表现，在病理和治疗层面都具有挑战性。它常与肝硬化相关，但也可能由骨髓增生性疾病、各种胃肠来源的癌症、腹部感染和血栓形成倾向引起。一部分内脏静脉血栓形成仍被归类为特发性。在这里，我们回顾了内脏静脉血栓形成的机制，包括克隆性造血在特发性 SVT 发病机制中的作用的新见解，这从治疗角度具有重要意义。
