Venault P, Chapouthier G, Simiand J, Dodd R H, Rossier J
Laboratoire de Physiologie Nerveuse, C.N.R.S., Gif-sur-Yvette, France.
Brain Res Bull. 1987 Sep;19(3):365-70. doi: 10.1016/0361-9230(87)90105-5.
Benzodiazepines are known to induce a profound anterograde amnesia in man. In this report, it is shown that methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the benzodiazepine receptor, has the opposite effect; it enhances performance in learning and memory tasks. Three different learning models were used: habituation to a new environment and passive avoidance in mice and imprinting in chicks. The opposite effects of both beta-CCM and the benzodiazepine diazepam were blocked by administration of the benzodiazepine receptor antagonist Ro 15-1788, providing evidence that the benzodiazepine receptor is involved in these effects.
众所周知，苯二氮䓬类药物会在人体中引发严重的顺行性遗忘。在本报告中，研究表明，苯二氮䓬受体的反向激动剂β-咔啉-3-羧酸甲酯（β-CCM）具有相反的作用；它能提高学习和记忆任务的表现。使用了三种不同的学习模型：小鼠对新环境的习惯化和被动回避以及小鸡的印记学习。β-CCM和苯二氮䓬类药物地西泮的相反作用可通过给予苯二氮䓬受体拮抗剂Ro 15-1788来阻断，这证明苯二氮䓬受体参与了这些作用。
