Anglade F, Bizot J C, Dodd R H, Baudoin C, Chapouthier G
DGA/ETCA/CEB, Vert-le-Petit, France.
Neurosci Lett. 1994 Dec 5;182(2):247-50. doi: 10.1016/0304-3940(94)90808-7.
Benzodiazepine (Bzd) agonist, diazepam (Dzp) and inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM); acetylcholinesterase inhibitor, physostigmine (Physo) and muscarinic antagonist, scopolamine (Scopo), were investigated for their mnesic effect in a passive avoidance (PA) task in rats. Impairments were observed after Dzp- and/or Scopo-pretraining treatments. Physo was without effect but antagonized the Dzp-induced impairments. beta-CCM enhanced acquisition and antagonized the Scopo-induced impairing effect. All these drugs had no effect in posttraining administration.
研究了苯二氮䓬（Bzd）激动剂地西泮（Dzp）和反向激动剂甲基β-咔啉-3-羧酸酯（β-CCM）；乙酰胆碱酯酶抑制剂毒扁豆碱（Physo）和毒蕈碱拮抗剂东莨菪碱（Scopo）对大鼠被动回避（PA）任务记忆效应的影响。在Dzp和/或Scopo预训练处理后观察到记忆损伤。Physo没有效果，但拮抗了Dzp诱导的损伤。β-CCM增强了记忆获得并拮抗了Scopo诱导的损伤效应。所有这些药物在训练后给药时均无效果。
