National Institute R&D for Isotopic and Molecular Technology, 67-103 Donat Street, 400293 Cluj-Napoca, Romania.
Department of Neurosurgery, "Grigore T. Popa" University of Medicine and Pharmacy, Str. Universității nr. 16, 700115 Iasi, Romania.
Int J Mol Sci. 2023 Jan 26;24(3):2452. doi: 10.3390/ijms24032452.
Shape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron-palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesium and pure iron, two metals commonly used in temporary stent research. In order to avoid blood clotting upon the introduction of the stent, they are often coated with anticoagulants. In this study, sulfated pectin, a heparin mimetic, was synthesized in different ways and used as coating on multiple iron-palladium alloys. The static and dynamic prothrombin time (PT) and activated partial thromboplastin time (APTT) of the prepared materials were compared to samples uncoated or coated with polyethylene glycol. While no large differences were observed in the prothrombin time measurements, the activated partial thromboplastin time increased significantly with all alloys coated with sulfated pectin. Aside from that, sulfated pectin synthesized by different methods also caused slight changes in the activated partial thromboplastin time. These findings show that iron-palladium alloys can be coated with anticoagulants to improve their utility as material for temporary stents. Sulfated pectin was characterized by nuclear magnetic resonance (NMR) and Fourier-transform infrared (FTIR) spectroscopy, and the coated alloys by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX).
形状记忆合金，特别是铁磁性形状记忆合金，是制造支架的有趣新材料。特别是铁-钯合金，由于其降解率介于镁和纯铁之间，而镁和纯铁是两种常用于临时支架研究的金属，因此可用于制造自扩张临时支架。为了避免支架引入后发生血栓形成，它们通常涂有抗凝剂。在这项研究中，合成了不同方法的硫酸化果胶，一种肝素类似物，并用作多种铁-钯合金的涂层。将制备的材料的静态和动态凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）与未涂层或涂覆有聚乙二醇的样品进行比较。虽然在凝血酶原时间测量中没有观察到很大的差异，但所有涂覆有硫酸化果胶的合金的活化部分凝血活酶时间显著增加。除此之外，用不同方法合成的硫酸化果胶也会导致活化部分凝血活酶时间略有变化。这些发现表明，铁-钯合金可以涂覆抗凝剂以提高其作为临时支架材料的用途。通过核磁共振（NMR）和傅里叶变换红外（FTIR）光谱对硫酸化果胶进行了表征，并通过扫描电子显微镜（SEM）和能量色散 X 射线分析（EDX）对涂覆的合金进行了表征。
