甲胎蛋白、磷脂酰肌醇蛋白聚糖-3和激肽原-1作为肝细胞癌诊断的生物标志物。
Alpha-fetoprotein, glypican-3, and kininogen-1 as biomarkers for the diagnosis of hepatocellular carcinoma.
作者信息
Domínguez-Lazcano Diana Gabriela, Simón-Lara Ingrid, Morales-Romero Jaime, Vásquez-Garzón Verónica Rocío, Arroyo-Helguera Omar Elind, López-Vazquez Julieta, Campos-Parra Alma D, Hernández-Nopaltecatl Brayan, Rivera-Hernández Ximena Andrea, Quintana Sofía, García-Román Rebeca
机构信息
Instituto de Salud Pública, Universidad Veracruzana Xalapa, Veracruz, México.
Facultad de Medicina, Región Poza-Rica-Tuxpan, Universidad Veracruzana Xalapa, Veracruz, México.
出版信息
Int J Clin Exp Pathol. 2024 Nov 15;17(11):383-395. doi: 10.62347/QSII4050. eCollection 2024.
The hepatocarcinoma (HCC) is the most important liver tumor. It represents 90% of liver cancer cases. One of the main problems is the limited prompt cancer diagnosis and the advanced stages where the chances of treatment are limited. The main diagnostic methods for HCC are imaging techniques and liver biopsy. With advances in technology, proteins as significant diagnostic biomarkers have increased. The objective of this review is to describe the role of Alpha-fetoprotein (AFP), Glipican 3 (GPC-3), and Kininogen 1 (KNG-1) as biomarkers for the diagnosis of hepatocellular carcinoma. A systematic search of studies was carried out in the literature and the diagnostic values of these proteins were compared. The results showed that the combined use of biomarkers increases the diagnostic capacity for the detection of hepatocellular carcinoma.
肝癌（HCC）是最重要的肝脏肿瘤。它占肝癌病例的90%。主要问题之一是癌症早期诊断受限，且处于治疗机会有限的晚期阶段。肝癌的主要诊断方法是成像技术和肝活检。随着技术的进步，作为重要诊断生物标志物的蛋白质有所增加。本综述的目的是描述甲胎蛋白（AFP）、磷脂酰肌醇蛋白聚糖3（GPC - 3）和激肽原1（KNG - 1）作为肝细胞癌诊断生物标志物的作用。在文献中对研究进行了系统检索，并比较了这些蛋白质的诊断价值。结果表明，生物标志物的联合使用提高了肝细胞癌检测的诊断能力。
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