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The Role of Hepatitis Viruses as Drivers of Hepatocancerogenesis.肝炎病毒在肝癌发生过程中的驱动作用。
Cancers (Basel). 2024 Apr 15;16(8):1505. doi: 10.3390/cancers16081505.
2
A Statistical Approach to the Diagnosis and Prediction of HCC Using CK19 and Glypican 3 Biomarkers.一种使用CK19和磷脂酰肌醇蛋白聚糖3生物标志物对肝癌进行诊断和预测的统计方法。
Diagnostics (Basel). 2023 Mar 27;13(7):1253. doi: 10.3390/diagnostics13071253.
3
Glypican-3, Vascular Endothelial Growth Factor and Golgi Protein-73 for Differentiation between Liver Cirrhosis and Hepatocellular Carcinoma.磷脂酰基醇蛋白 3、血管内皮生长因子和高尔基糖蛋白 73 鉴别肝硬化与肝细胞癌。
Asian Pac J Cancer Prev. 2023 Feb 1;24(2):497-507. doi: 10.31557/APJCP.2023.24.2.497.
4
The Role of Alpha-Fetoprotein (AFP) in Contemporary Oncology: The Path from a Diagnostic Biomarker to an Anticancer Drug.甲胎蛋白（AFP）在当代肿瘤学中的作用：从诊断生物标志物到抗癌药物。
Int J Mol Sci. 2023 Jan 28;24(3):2539. doi: 10.3390/ijms24032539.
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Diagnostic accuracy and prognostic significance of Glypican-3 in hepatocellular carcinoma: A systematic review and meta-analysis.Glypican-3在肝细胞癌中的诊断准确性及预后意义：一项系统评价与Meta分析
Front Oncol. 2022 Sep 23;12:1012418. doi: 10.3389/fonc.2022.1012418. eCollection 2022.
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Novel Nanotechnology Approaches to Overcome Drug Resistance in the Treatment of Hepatocellular Carcinoma: Glypican 3 as a Useful Target for Innovative Therapies.新型纳米技术方法克服肝癌治疗中的药物耐药性：Glypican 3 作为创新疗法的有用靶点。
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9
Common Sensitive Diagnostic and Prognostic Markers in Hepatocellular Carcinoma and Their Clinical Significance: A Review.肝细胞癌常见敏感诊断和预后标志物及其临床意义：综述
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甲胎蛋白、磷脂酰肌醇蛋白聚糖-3和激肽原-1作为肝细胞癌诊断的生物标志物。

Alpha-fetoprotein, glypican-3, and kininogen-1 as biomarkers for the diagnosis of hepatocellular carcinoma.

作者信息

Domínguez-Lazcano Diana Gabriela, Simón-Lara Ingrid, Morales-Romero Jaime, Vásquez-Garzón Verónica Rocío, Arroyo-Helguera Omar Elind, López-Vazquez Julieta, Campos-Parra Alma D, Hernández-Nopaltecatl Brayan, Rivera-Hernández Ximena Andrea, Quintana Sofía, García-Román Rebeca

机构信息

Instituto de Salud Pública, Universidad Veracruzana Xalapa, Veracruz, México.

Facultad de Medicina, Región Poza-Rica-Tuxpan, Universidad Veracruzana Xalapa, Veracruz, México.

出版信息

Int J Clin Exp Pathol. 2024 Nov 15;17(11):383-395. doi: 10.62347/QSII4050. eCollection 2024.

DOI:10.62347/QSII4050
PMID:39660335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626288/
Abstract

The hepatocarcinoma (HCC) is the most important liver tumor. It represents 90% of liver cancer cases. One of the main problems is the limited prompt cancer diagnosis and the advanced stages where the chances of treatment are limited. The main diagnostic methods for HCC are imaging techniques and liver biopsy. With advances in technology, proteins as significant diagnostic biomarkers have increased. The objective of this review is to describe the role of Alpha-fetoprotein (AFP), Glipican 3 (GPC-3), and Kininogen 1 (KNG-1) as biomarkers for the diagnosis of hepatocellular carcinoma. A systematic search of studies was carried out in the literature and the diagnostic values of these proteins were compared. The results showed that the combined use of biomarkers increases the diagnostic capacity for the detection of hepatocellular carcinoma.

摘要

肝癌（HCC）是最重要的肝脏肿瘤。它占肝癌病例的90%。主要问题之一是癌症早期诊断受限，且处于治疗机会有限的晚期阶段。肝癌的主要诊断方法是成像技术和肝活检。随着技术的进步，作为重要诊断生物标志物的蛋白质有所增加。本综述的目的是描述甲胎蛋白（AFP）、磷脂酰肌醇蛋白聚糖3（GPC - 3）和激肽原1（KNG - 1）作为肝细胞癌诊断生物标志物的作用。在文献中对研究进行了系统检索，并比较了这些蛋白质的诊断价值。结果表明，生物标志物的联合使用提高了肝细胞癌检测的诊断能力。