Departamento de Medicina Interna, Universidad de La Laguna, Servicio de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, 38320 La Laguna, Spain.
Departamento de Ciencias Médicas Básicas, Unidad de Fisiología, Universidad de la Laguna, Tenerife, Canary Islands, 38320 La Laguna, Spain.
Nutrients. 2022 Jun 22;14(13):2574. doi: 10.3390/nu14132574.
Sclerostin was initially described as an inhibitor of the Wnt-β catenin bone-forming pathway, but it also exerts important effects on intermediate metabolism and body composition. Osteosarcopenia and altered body fat distribution are common findings in excessive drinkers. The role of sclerostin in these patients is uncertain. We aim to analyze the behavior of sclerostin in excessive drinkers and its relationships with body composition (fat mass, lean mass, bone mass), handgrip strength, body mass index (BMI), liver function and ethanol intake.
107 male active heavy drinkers and 26 age-matched controls were included. Serum sclerostin was determined by ELISA. Body composition analysis was performed by double X-ray absorptiometry. Handgrip strength was recorded using a dynamometer. Liver function was assessed according to Child's classification.
Sclerostin was higher among Child's C patients, keeping a relationship with deranged liver function. Obesity, defined according to BMI, and body fat were strongly related to sclerostin, being independent of serum creatinine and of liver function. The relationship of sclerostin with total hip bone mineral density was displaced by BMI.
Deranged liver function is associated with higher sclerostin levels in alcoholics. Raised sclerostin levels are related to fat deposition and increased BMI.
最初，骨硬化蛋白被描述为 Wnt-β 连环蛋白成骨途径的抑制剂，但它对中间代谢和身体成分也有重要影响。骨质疏松和体脂分布改变是过量饮酒者常见的发现。骨硬化蛋白在这些患者中的作用尚不确定。我们旨在分析过量饮酒者骨硬化蛋白的行为及其与身体成分（脂肪量、瘦体量、骨量）、握力、体重指数（BMI）、肝功能和乙醇摄入量的关系。
纳入 107 名活跃的男性重度饮酒者和 26 名年龄匹配的对照者。通过 ELISA 法测定血清骨硬化蛋白。通过双 X 射线吸收法进行身体成分分析。使用测力计记录握力。根据 Child 分类评估肝功能。
Child C 级患者的骨硬化蛋白水平较高，与肝功能异常有关。根据 BMI 定义的肥胖和体脂与骨硬化蛋白密切相关，与血清肌酐和肝功能无关。骨硬化蛋白与全髋关节骨矿物质密度的关系被 BMI 取代。
肝功能异常与酒精中毒者骨硬化蛋白水平升高有关。骨硬化蛋白水平升高与脂肪沉积和 BMI 增加有关。
