Konsek-Komorowska Sonia J, Pęczkowska Mariola, Kolasińska-Ćwikła Agnieszka D, Cichocki Andrzej, Konka Marek, Roszkowska-Purska Katarzyna, Ćwikła Jarosław B
Department of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
The Cardinal Stefan Wyszyński National Institute of Cardiology, 04-628 Warsaw, Poland.
J Clin Med. 2023 Jan 19;12(3):790. doi: 10.3390/jcm12030790.
Neuroendocrine neoplasms of the small intestine (SI-NENs) are one of the most commonly recognized gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Carcinoid heart disease (CHD) is the primary cause of death in patients with the carcinoid syndrome (CS). The aim of this retrospective study was to evaluate possible factors impacting upon overall survival (OS) in subjects with both neuroendocrine tumors (NETs) G1/G2 of the small intestine (SI-NET) and CHD. Enrolled in our study of 275 patients with confirmed G1/G2 SI-NET, were 28 (10%) individuals with CHD. Overall survival was assessed using the Kaplan-Meier method. The Cox-Mantel test was used to determine how OS varied between groups. A Cox proportional hazards model was used to conduct univariate analyses of predictive factors for OS and estimate hazard ratios (HRs). Of the 28 individuals with confirmed carcinoid heart disease, 12 (43%) were found to have NET G1 and 16 (57%) were found to have NET G2. Univariate analysis revealed that subjects with CHD and without resection of the primary tumor had a lower OS. Our retrospective study observed that patients who presented with CHD and without resection of primary tumor had worse prognosis of survival. These results suggest that primary tumors may need to be removed when feasible, but further research is needed. However, no solid recommendations can be issued on the basis of our single retrospective study.
小肠神经内分泌肿瘤（SI-NENs）是最常见的胃肠胰神经内分泌肿瘤（GEP-NENs）之一。类癌性心脏病（CHD）是类癌综合征（CS）患者的主要死因。这项回顾性研究的目的是评估影响小肠神经内分泌肿瘤（SI-NET）G1/G2和CHD患者总生存期（OS）的可能因素。我们纳入了275例确诊为G1/G2 SI-NET的患者，其中28例（10%）患有CHD。采用Kaplan-Meier方法评估总生存期。使用Cox-Mantel检验确定各组间OS的差异。采用Cox比例风险模型对OS的预测因素进行单因素分析并估计风险比（HRs）。在28例确诊为类癌性心脏病的患者中，12例（43%）为NET G1，16例（57%）为NET G2。单因素分析显示，患有CHD且未切除原发肿瘤的患者OS较低。我们的回顾性研究观察到，患有CHD且未切除原发肿瘤的患者生存预后较差。这些结果表明，可行时可能需要切除原发肿瘤，但还需要进一步研究。然而，基于我们单一的回顾性研究无法给出确凿的建议。
