Porriño-Bustamante María Librada, Montero-Vílchez Trinidad, Fernández-Pugnaire María Antonia, Arias-Santiago Salvador
Dermatology Department, University Hospital La Zarzuela, 28023 Madrid, Spain.
Dermatology Department, University of Granada, 18016 Granada, Spain.
J Clin Med. 2023 Jan 20;12(3):824. doi: 10.3390/jcm12030824.
Quality of life (QoL) can be affected in patients with alopecia. The few studies that evaluate QoL in FFA use unspecific questionnaires. The aim of this report was to design and validate a specific questionnaire to assess the impairment of QoL in FFA patients. A specific questionnaire, called the Frontal Fibrosing Alopecia Quality of Life Index (FFA-QLI), was designed and validated using the Dermatology Life Quality Index (DLQI). One-hundred and one women with FFA were included. Cronbach's alpha value was 0.865, and the intraclass correlation coefficient between all the items in the questionnaire was 0.870. The FFA-QLI correlated positively with the DLQI (r = 0.729, < 0.001). Patients with severe FFA showed a higher FFA-QLI (19.72) score compared to those with a mild disease (14.11) ( = 0.002), and the area under the curve for identifying severe disease was greater in the FFA-QLI than in the DLQI. The cut-off points were used to select patients with mild, moderate, and severe impairment in QoL. A score < 21 in the FFA-QLI corresponded to a low impact on QoL; values > 35 matched with greater QoL impairment; and values ranging from 21 to 35 corresponded to moderate QoL alteration. To conclude, a validated disease-specific questionnaire to assess QoL in FFA patients is here presented, with a greater power to discriminate severe cases of FFA than the DLQI.
脱发患者的生活质量（QoL）可能会受到影响。少数评估瘢痕性前额纤维性脱发（FFA）患者生活质量的研究使用的是非特异性问卷。本报告的目的是设计并验证一份特定问卷，以评估FFA患者生活质量的受损情况。我们设计了一份名为前额纤维性脱发生活质量指数（FFA-QLI）的特定问卷，并使用皮肤病生活质量指数（DLQI）进行了验证。纳入了101名患有FFA的女性。克朗巴哈系数值为0.865，问卷中所有项目之间的组内相关系数为0.870。FFA-QLI与DLQI呈正相关（r = 0.729，<0.001）。与轻度疾病患者（14.11）相比，重度FFA患者的FFA-QLI得分更高（19.72）（= 0.002），并且FFA-QLI在识别严重疾病方面的曲线下面积大于DLQI。使用这些分界点来选择生活质量有轻度、中度和重度受损的患者。FFA-QLI得分<21对应于对生活质量的低影响；值>35与更大的生活质量受损相匹配；值在21至35之间对应于中度生活质量改变。总之，本文提出了一份经过验证的针对疾病的问卷，用于评估FFA患者的生活质量，与DLQI相比，它在区分重度FFA病例方面具有更强的能力。
