Laroche C, Sheiner R, Lester E, Benierakis C, Marrache M, Engelsmann F, Cheifetz P
McGill University, Montreal, Quebec.
Can J Psychiatry. 1987 Oct;32(7):563-9. doi: 10.1177/070674378703200711.
Thirty-seven offspring from 21 families with a manic-depressive parent were studied 3 to 7 years following initial evaluation. The study examined both pedigree information and psychosocial variables including parental, marital and overall adjustment, measures of chronicity and severity of parental illness and family assessment measures in relationship to offspring functioning. Nine of the 37 offspring (24%) received a positive DSM-III diagnosis, which is a similar percentage of positive diagnosis of children as we found previously. The diagnoses clustered in the affective illness spectrum. When the presence of affective traits was considered, there was evidence for continuity of psychopathology in most cases. Associations between offspring psychopathology and both non-specific and specific parental risk factors are discussed.
对来自21个有躁郁症患者的家庭的37名后代在初次评估后的3至7年进行了研究。该研究考察了系谱信息和社会心理变量，包括父母、婚姻和整体适应情况、父母疾病的慢性程度和严重程度指标以及与后代功能相关的家庭评估指标。37名后代中有9名（24%）获得了DSM-III的阳性诊断，这一阳性诊断比例与我们之前在儿童中发现的相似。诊断集中在情感性疾病范围内。当考虑情感特质的存在时，大多数情况下有精神病理学连续性的证据。讨论了后代精神病理学与非特异性和特异性父母风险因素之间的关联。
