Farchione Tiffany R, Birmaher Boris, Axelson David, Kalas Cathy, Monk Kelly, Ehmann Mary, Iyengar Satish, Kupfer David, Brent David
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA.
Bipolar Disord. 2007 Aug;9(5):496-503. doi: 10.1111/j.1399-5618.2007.00390.x.
To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP).
Using the parent and the child versions of the Children's Hostility Inventory (CHI), we assessed aggression, hostility, and irritability in 300 offspring aged 6-18 years old of BP parents and 169 children of community controls.
Children of BP parents have significantly higher scores on the total CHI and its subscales than do children of control parents. After adjusting for demographic variables, both parents' non-BP psychopathology, child psychopathology, and within-family correlations, three factors remain significant: total CHI by parent rating, irritability subscale by parent rating, and irritability by child self-report. The hostility subscale by parent rating became a trend.
Children of BP parents score higher on ratings of hostility and irritability than children of community control parents, independent of child psychopathology and non-BP parental psychopathology. Follow-up of these children to evaluate whether these symptoms are markers for the development of BP or mood disorders is warranted.
评估双相情感障碍（BP）风险儿童的攻击性、易怒性和敌意。
我们使用儿童敌意量表（CHI）的家长版和儿童版，对300名6至18岁双相情感障碍患者的后代以及169名社区对照儿童的攻击性、敌意和易怒性进行了评估。
双相情感障碍患者后代在CHI总分及其子量表上的得分显著高于对照儿童。在调整人口统计学变量、父母的非双相情感障碍精神病理学、儿童精神病理学以及家庭内部相关性后，有三个因素仍然显著：家长评定的CHI总分、家长评定的易怒性子量表以及儿童自我报告的易怒性。家长评定的敌意子量表呈一种趋势。
双相情感障碍患者的后代在敌意和易怒性评分上高于社区对照儿童，与儿童精神病理学和非双相情感障碍的父母精神病理学无关。有必要对这些儿童进行随访，以评估这些症状是否是双相情感障碍或情绪障碍发展的标志。
