Nedelcu Liviu, Ferreira José M F, Popa Adrian-Claudiu, Amarande Luminița, Nan Bo, Bălescu Liliana-Marinela, Geambașu Cezar Dragoș, Cioangher Marius-Cristian, Leonat Lucia, Grigoroscuță Mihai, Cristea Daniel, Stroescu Hermine, Ciocoiu Robert Cătălin, Stan George E
National Institute of Materials Physics, 077125 Magurele, Romania.
Department of Materials and Ceramic Engineering, CICECO-Aveiro Materials Institute, University of Aveiro, 3810-193 Aveiro, Portugal.
Materials (Basel). 2023 Jan 17;16(3):901. doi: 10.3390/ma16030901.
This work was devoted to the first multi-parametric unitary comparative analysis of a selection of sintered piezoceramic materials synthesised by solid-state reactions, aiming to delineate the most promising biocompatible piezoelectric material, to be further implemented into macro-porous ceramic scaffolds fabricated by 3D printing technologies. The piezoceramics under scrutiny were: KNbO, LiNbO, LiTaO, BaTiO, Zr-doped BaTiO, and the (BaCa)(TiZr)O solid solution (BCTZ). The XRD analysis revealed the high crystallinity of all sintered ceramics, while the best densification was achieved for the BaTiO-based materials via conventional sintering. Conjunctively, BCTZ yielded the best combination of functional properties-piezoelectric response (in terms of longitudinal piezoelectric constant and planar electromechanical coupling factor) and mechanical and in vitro osteoblast cell compatibility. The selected piezoceramic was further used as a base material for the robocasting fabrication of 3D macro-porous scaffolds (porosity of ~50%), which yielded a promising compressive strength of ~20 MPa (higher than that of trabecular bone), excellent cell colonization capability, and noteworthy cytocompatibility in osteoblast cell cultures, analogous to the biological control. Thereby, good prospects for the possible development of a new generation of synthetic bone graft substitutes endowed with the piezoelectric effect as a stimulus for the enhancement of osteogenic capacity were settled.
这项工作致力于对通过固态反应合成的一系列烧结压电陶瓷材料进行首次多参数整体比较分析，旨在确定最有前景的生物相容性压电材料，以便进一步应用于通过3D打印技术制造的大孔陶瓷支架中。所研究的压电陶瓷包括：铌酸钾（KNbO）、铌酸锂（LiNbO）、钽酸锂（LiTaO）、钛酸钡（BaTiO）、锆掺杂钛酸钡（Zr-doped BaTiO）以及（BaCa）（TiZr）O固溶体（BCTZ）。X射线衍射（XRD）分析表明，所有烧结陶瓷都具有高结晶度，而通过传统烧结，钛酸钡基材料实现了最佳致密化。同时，BCTZ在功能特性方面表现最佳，具有压电响应（以纵向压电常数和平面机电耦合系数衡量）以及机械性能和体外成骨细胞相容性。所选的压电陶瓷进一步用作通过机器人铸造制造3D大孔支架（孔隙率约为50%）的基础材料，该支架具有约20 MPa的抗压强度（高于松质骨）、出色的细胞定植能力以及在成骨细胞培养中值得注意的细胞相容性，类似于生物对照。因此，为新一代具有压电效应以刺激成骨能力增强的合成骨移植替代物的可能开发奠定了良好前景。
