Wu Yanlong, Chen Ruomeng, Chen Xu, Yang Yongqiang, Qiao Jian, Liu Yaxiong
School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China.
Ji Hua Laboratory, Foshan 528200, China.
Materials (Basel). 2023 Jan 19;16(3):947. doi: 10.3390/ma16030947.
Strong and tough β-TCP/PCL composite scaffolds with interconnected porosity were developed by combining digital light processing and vacuum infiltration. The composite scaffolds were comprised of pure β-TCP, β-TCP matrix composite and PCL matrix composite. The porous β-TCP/PCL composite scaffolds showed remarkable mechanical advantages compared with ceramic scaffolds with the same macroscopic pore structure (dense scaffolds). The composite scaffolds exhibited a significant increase in strain energy density and fracture energy density, though with similar compressive and flexural strengths. Moreover, the composite scaffolds had a much higher Weibull modulus and longer fatigue life than the dense scaffolds. It was revealed that the composite scaffolds with interconnected porosity possess comprehensive mechanical properties (high strength, excellent toughness, significant reliability and fatigue resistance), which suggests that they could replace the pure ceramic scaffolds for degradable bone substitutes, especially in complex stress environments.
通过结合数字光处理和真空浸渍技术，制备出了具有相互连通孔隙的高强度韧性β-TCP/PCL复合支架。复合支架由纯β-TCP、β-TCP基复合材料和PCL基复合材料组成。与具有相同宏观孔隙结构的陶瓷支架（致密支架）相比，多孔β-TCP/PCL复合支架具有显著的力学优势。尽管复合支架的压缩强度和弯曲强度与致密支架相似，但其应变能密度和断裂能密度显著增加。此外，复合支架的威布尔模量比致密支架高得多，疲劳寿命也更长。研究表明，具有相互连通孔隙的复合支架具有综合力学性能（高强度、优异韧性、高可靠性和抗疲劳性），这表明它们可替代纯陶瓷支架用于可降解骨替代物，特别是在复杂应力环境中。
