体外评估聚己内酯富马酸酯聚合物涂层修饰的透辉石/钡铁氧体生物陶瓷支架。
In vitro evaluation of diopside/baghdadite bioceramic scaffolds modified by polycaprolactone fumarate polymer coating.
机构信息
Materials research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Mechanical Engineering Program, School of Science, Engineering and Technology, Pennsylvania State University, Harrisburg, Middletown, PA 17057, USA.
Materials research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
出版信息
Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110176. doi: 10.1016/j.msec.2019.110176. Epub 2019 Sep 10.
Porous Si-based ceramic scaffolds are widely attracted in biomedical tissue engineering application. Despite the attractive properties of these materials, their weak mechanical properties and high degradability in vitro and in vivo environment can limit their application as biomedical devises. Applying a thin layer of polymer on the surface of porous scaffolds can improve the mechanical properties and control the degradation rate. In this study, we produced new modified scaffolds with polymers coating in order to improved mechanical and biological properties of Si-based ceramics scaffolds. The results showed that applying 6 wt% PCLF polymer on the surface of Bagh-15 wt%Dio scaffolds delayed apatite formation compared to unmodified scaffolds. On the other hand, in the modified scaffolds, apatite formation was observed. The degradation rate of unmodified scaffolds was decreased around 82% after 28 days soaking in PBS solution. Based on the MTT assay and SEM micrographs, the BMS cells were spread and attached well on the surface of the scaffolds, which indicated a good biocompatibility. The results showed that these scaffolds have the potential to be used as a temporary substrate for bone tissue engineering application.
多孔硅基陶瓷支架在生物医学组织工程应用中受到广泛关注。尽管这些材料具有吸引人的特性，但它们在体外和体内环境中的机械强度低和高降解性可能限制它们作为生物医学器件的应用。在多孔支架表面涂覆一层聚合物可以改善其机械性能并控制降解速率。在这项研究中，我们制备了具有聚合物涂层的新型改性支架，以改善硅基陶瓷支架的机械和生物学性能。结果表明，与未改性支架相比，在 Bagh-15wt%Dio 支架表面涂覆 6wt%PCLF 聚合物可延迟磷灰石形成。另一方面，在改性支架中观察到了磷灰石的形成。在 PBS 溶液中浸泡 28 天后，未改性支架的降解率降低了约 82%。基于 MTT 测定和 SEM 显微照片，BMS 细胞在支架表面展开并良好附着，表明其具有良好的生物相容性。结果表明，这些支架有可能作为骨组织工程应用的临时支架。
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