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迈向具有空间可控离子取代的智能仿生磷灰石基骨支架

Toward Smart Biomimetic Apatite-Based Bone Scaffolds with Spatially Controlled Ion Substitutions.

作者信息

Cianflone Edoardo, Brouillet Fabien, Grossin David, Soulié Jérémy, Josse Claudie, Vig Sanjana, Fernandes Maria Helena, Tenailleau Christophe, Duployer Benjamin, Thouron Carole, Drouet Christophe

机构信息

CIRIMAT, Université de Toulouse, CNRS, INP-ENSIACET, 31030 Toulouse, France.

CIRIMAT, Université de Toulouse, CNRS, UT3 Paul Sabatier, 31062 Toulouse, France.

出版信息

Nanomaterials (Basel). 2023 Jan 28;13(3):519. doi: 10.3390/nano13030519.

DOI:10.3390/nano13030519
PMID:36770480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9919144/
Abstract

Biomimetic apatites exhibit a high reactivity allowing ion substitutions to modulate their in vivo response. We developed a novel approach combining several bioactive ions in a spatially controlled way in view of subsequent releases to address the sequence of events occurring after implantation, including potential microorganisms' colonization. Innovative micron-sized core-shell particles were designed with an external shell enriched with an antibacterial ion and an internal core substituted with a pro-angiogenic or osteogenic ion. After developing the proof of concept, two ions were particularly considered, Ag in the outer shell and Cu in the inner core. In vitro evaluations confirmed the cytocompatibility through Ag-/Cu-substituting and the antibacterial properties provided by Ag. Then, these multifunctional "smart" particles were embedded in a polymeric matrix by freeze-casting to prepare 3D porous scaffolds for bone engineering. This approach envisions the development of a new generation of scaffolds with tailored sequential properties for optimal bone regeneration.

摘要

仿生磷灰石具有高反应活性，能够进行离子置换以调节其体内反应。考虑到后续释放，我们开发了一种新颖的方法，以空间可控的方式结合多种生物活性离子，以应对植入后发生的一系列事件，包括潜在微生物的定植。设计了创新的微米级核壳颗粒，其外壳富含抗菌离子，内核则被促血管生成或成骨离子取代。在验证了概念验证后，特别考虑了两种离子，外壳中的银和内核中的铜。体外评估通过银/铜置换证实了细胞相容性以及银提供的抗菌性能。然后，通过冷冻铸造将这些多功能“智能”颗粒嵌入聚合物基质中，以制备用于骨工程的三维多孔支架。这种方法设想开发具有定制顺序特性的新一代支架，以实现最佳的骨再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/124ddc433fda/nanomaterials-13-00519-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/527fccc646e3/nanomaterials-13-00519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/2e73d19ed33c/nanomaterials-13-00519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/ff53c350ccd2/nanomaterials-13-00519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/8697310c3b70/nanomaterials-13-00519-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/1c2669915ea6/nanomaterials-13-00519-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/1b086e840251/nanomaterials-13-00519-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/b4a248fdcc54/nanomaterials-13-00519-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/617074ca3b14/nanomaterials-13-00519-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/fb1847c95200/nanomaterials-13-00519-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/124ddc433fda/nanomaterials-13-00519-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/527fccc646e3/nanomaterials-13-00519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/2e73d19ed33c/nanomaterials-13-00519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/ff53c350ccd2/nanomaterials-13-00519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/8697310c3b70/nanomaterials-13-00519-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/1c2669915ea6/nanomaterials-13-00519-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/1b086e840251/nanomaterials-13-00519-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/b4a248fdcc54/nanomaterials-13-00519-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/617074ca3b14/nanomaterials-13-00519-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/fb1847c95200/nanomaterials-13-00519-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80f2/9919144/124ddc433fda/nanomaterials-13-00519-g010.jpg

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