Department of Chemistry, Illinois State University, Normal, IL 61790-4160, USA.
Molecules. 2023 Jan 18;28(3):946. doi: 10.3390/molecules28030946.
In this study, a specific alkylphenol natural product, anaephene B, and its unique synthesized derivatives were tested for their inhibitory effect on the protozoan parasite . In a series of cell viability tests and enzyme assays, these test compounds have produced interesting results with regard to their antibiotic effect, showing similar potency against as they do against drug-resistant bacteria such as methicillin-resistant (MRSA). All compounds tested in this study have shown the ability to completely inhibit our model system, in vitro. This study helps increase our understanding of the structure-activity relationship (SAR) between anaephene B and its analogues for a new class of potential pharmaceuticals for the treatment of infections.
在这项研究中，一种特定的烷基酚天然产物——阿那菲恩 B 及其独特的合成衍生物被测试其对原生动物寄生虫的抑制作用。在一系列细胞活力测试和酶测定中，这些测试化合物在抗生素作用方面产生了有趣的结果，它们对 的效力与对耐甲氧西林金黄色葡萄球菌（MRSA）等耐药细菌的效力相似。本研究中测试的所有化合物都表现出能够完全抑制我们的体外模型系统 的能力。这项研究有助于增加我们对阿那菲恩 B 及其类似物之间的结构-活性关系（SAR）的理解，为治疗 感染的一类新的潜在药物提供了依据。
