Potent Inhibitory Activity of Natural Product Anaephene B and Analogues against In Vitro.

In this study, a specific alkylphenol natural product, anaephene B, and its unique synthesized derivatives were tested for their inhibitory effect on the protozoan parasite . In a series of cell viability tests and enzyme assays, these test compounds have produced interesting results with regard to their antibiotic effect, showing similar potency against as they do against drug-resistant bacteria such as methicillin-resistant (MRSA). All compounds tested in this study have shown the ability to completely inhibit our model system, in vitro. This study helps increase our understanding of the structure-activity relationship (SAR) between anaephene B and its analogues for a new class of potential pharmaceuticals for the treatment of infections.