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Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.钩果藤中的卡那巴酸作为 Bcl-xL/Bak 和 Mcl-1/Bid 相互作用调节剂。
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从丝状蓝藻（Hormoscilla sp.，颤藻目）中分离和表征 Anaephenes A-C，烷基酚。

Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales).

机构信息

Smithsonian Marine Station at Ft. Pierce , 701 Seaway Drive , Ft. Pierce , Florida 34949 , United States.

University of Guam Marine Laboratory , Mangilao , Guam 96923 , United States.

出版信息

J Nat Prod. 2018 Dec 28;81(12):2716-2721. doi: 10.1021/acs.jnatprod.8b00650. Epub 2018 Nov 29.

DOI:10.1021/acs.jnatprod.8b00650
PMID:30489078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7315913/
Abstract

Three related new alkylphenols, termed anaephenes A-C (1-3), containing different side chains, were isolated from an undescribed filamentous cyanobacterium (VPG 16-59) collected in Guam. Our 16S rDNA sequencing efforts indicated that VPG 16-59 is a member of the marine genus Hormoscilla (Oscillatoriales). The structures of anaephenes A-C (1-3) were elucidated by spectroscopic methods, and compounds assayed for growth inhibitory activity against prokaryotic and eukaryotic cell lines. Anaephene B (2), possessing a terminal alkyne, displayed moderate activity against Bacillus cereus and Staphylococcus aureus with MIC values of 6.1 μg/mL. While 1 and 3 showed no pronounced activity in these assays, their structural features highlight the unusual biosynthetic capacity of this cyanobacterium and warrant further study.

摘要

从关岛采集的一种未描述的丝状蓝藻（VPG 16-59）中分离出三种相关的新型烷基酚，分别称为 anaephenes A-C（1-3），它们含有不同的侧链。我们的 16S rDNA 测序结果表明，VPG 16-59 是海洋属 Hormoscilla（Oscillatoriales）的成员。anaephenes A-C（1-3）的结构通过光谱方法阐明，并对其抑制真核和原核细胞系生长的活性进行了测定。具有末端炔烃的 anaephene B（2）对蜡状芽孢杆菌和金黄色葡萄球菌显示出中等的活性，MIC 值分别为 6.1μg/mL。虽然 1 和 3 在这些测定中没有表现出明显的活性，但它们的结构特征突出了这种蓝藻的异常生物合成能力，值得进一步研究。